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The role of uterus mitochondrial function in high-fat diet-related adverse pregnancy outcomes and protection by resveratrol

文献类型： 外文期刊

作者： Yang, Xizi;Hu, Ruizhi;Yao, Liping;Zhang, Wentao;Shi, Mingkun;Gong, Jiatai;Yuan, Xupeng;Li, Yanli;Yan, Jiahao;Wang, Ying;Zhang, Qianjin;He, Ziyu;Hou, De-Xing;Fan, Zhiyong;Zhang, Hongfu;Chen, Liang;He, Xi;He, Jianhua;Wu, Shusong

作者机构：

期刊名称： FOOD & FUNCTION

ISSN： 2042-6496

年卷期： 2024 年

页码：

收录情况： SCIE（2024版） ; ; EI（2024版）

摘要： This study elucidates the mechanism of obesity-related adverse pregnancy outcomes and further investigates the effect of resveratrol on reproductive performance in a short- or long-term HFD-induced obese mouse model. Results show that maternal weight had a significant positive correlation with litter mortality in mice. A long-term HFD increased body weight and litter mortality with decreased expression of uterine cytochrome oxidase 4 (COX4), which was recovered by resveratrol in mice. Moreover, HFD decreased the expression of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha), nuclear respiratory factors-1 (Nrf-1), and phosphorylated adenosine 5 '-monophosphate (AMP)-activated protein kinase (p-AMPK) and increased the expression of phosphorylated extracellular regulated protein kinases (p-ERK) in the uterus. Resveratrol, a polyphenol that can directly bind to the ERK protein, suppressed the phosphorylation of ERK, increased the expression of p-AMPK, PGC-1 alpha and Nrf-1, and decreased litter mortality in mice. This study elucidates the mechanism of obesity-related adverse pregnancy outcomes and further investigates the effect of resveratrol on reproductive performance in a short- or long-term HFD-induced obese mouse model.

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