数字农科院2.0

Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology

文献类型： 外文期刊

作者： Xiusheng Zhu;Qitong Huang;Jing Luo;Dashuai Kong;Yubo Zhang

作者机构：

关键词： Chromatin conformation;Gene regulatory network (GRN);Microscope imaging;Regulatory elements

期刊名称： Computational and Structural Biotechnology Journal

ISSN： 2001-0370

年卷期： 2023 年 21 卷

页码：

收录情况： SCIE（2023版） ; ; EI（2023版）

摘要： Gene regulatory networks are now at the forefront of precision biology, which can help researchers better understand how genes and regulatory elements interact to control cellular gene expression, offering a more promising molecular mechanism in biological research. Interactions between the genes and regulatory elements involve different promoters, enhancers, transcription factors, silencers, insulators, and long-range regulatory elements, which occur at a ∼10 µm nucleus in a spatiotemporal manner. In this way, three-dimensional chromatin conformation and structural biology are critical for interpreting the biological effects and the gene regulatory networks. In the review, we have briefly summarized the latest processes in three-dimensional chromatin conformation, microscopic imaging, and bioinformatics, and we have presented the outlook and future directions for these three aspects.

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