数字农科院2.0

Exploring the Role of Enhancer-Mediated Transcriptional Regulation in Precision Biology

文献类型： 外文期刊

作者： Xueyan Wang;Danli Liu;Jing Luo;Dashuai Kong;Yubo Zhang

作者机构：

关键词： enhancer-mediated;precision biology;three-dimensional (3D) genomics;transcriptional regulation

期刊名称： International journal of molecular sciences

ISSN： 1422-0067

年卷期： 2023 年 24 卷 13 期

页码：

收录情况： SCIE（2023版）

摘要： The emergence of precision biology has been driven by the development of advanced technologies and techniques in high-resolution biological research systems. Enhancer-mediated transcriptional regulation, a complex network of gene expression and regulation in eukaryotes, has attracted significant attention as a promising avenue for investigating the underlying mechanisms of biological processes and diseases. To address biological problems with precision, large amounts of data, functional information, and research on the mechanisms of action of biological molecules is required to address biological problems with precision. Enhancers, including typical enhancers and super enhancers, play a crucial role in gene expression and regulation within this network. The identification and targeting of disease-associated enhancers hold the potential to advance precision medicine. In this review, we present the concepts, progress, importance, and challenges in precision biology, transcription regulation, and enhancers. Furthermore, we propose a model of transcriptional regulation for multi-enhancers and provide examples of their mechanisms in mammalian cells, thereby enhancing our understanding of how enhancers achieve precise regulation of gene expression in life processes. Precision biology holds promise in providing new tools and platforms for discovering insights into gene expression and disease occurrence, ultimately benefiting individuals and society as a whole.

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