数字农科院2.0

Development and validation of a multi-residue analytical method for veterinarian and human pharmaceuticals in livestock urine and blood using UHPLC-QTOF

文献类型： 外文期刊

作者： Xue Wang;Ke-wen Wang;Zhen-zhen Xu;Shu-ming Yang;Yan Zhao

作者机构：

关键词： Drug residues; Livestock blood; Livestock urine; UHPLC-QTOF

期刊名称： J. Chromatogr. B Anal. Technol. Biomed. Life Sci.

ISSN： 1570-0232

年卷期： 2021 年 1167 卷

页码：

收录情况： JCR（2021版） ; EI（2021版）

摘要： The aim of this work is to contribute to the assessment of multi-residue analysis of veterinarian and human pharmaceuticals using UHPLC-QTOF in livestock urine and blood (cattle, chicken, sheep and pig). Firstly, an in-house database including compound name, monoisotopic mass, chemical formula, retention time, chemical structure, and three CID MS-MS spectra of the 234 selected drugs were built for qualitative detection. Secondly, the method validation result showed that all the 234 drugs exhibited good linearity with determination coefficients (R2) higher than 0.999. Then, the distribution of the drugs recoveries, intra-day RSD and inter-day RSD results for all seven matrices were tested. Finally, after a carefully cross check, 150 veterinarian and human pharmaceuticals could meet the methodological requirements (recovery, 50–120%; intra-day RSD ≤ 15%, inter-day RSD ≤ 20%) in all seven matrices. Our results suggested that although the main applications of UHPLC-QTOF are directed towards detection and identification of the compounds, this method should be also applied for quantitative purposes. © 2021 Elsevier B.V.

分类号：

  • 相关文献

[1]Metabolic Profile Of The Masked M.ycotoxin T-2 Toxin-3-Glucoside In R ats (In Vitro And In Vivo) And Humans (In Vitro). Yang, S, Van Poucke, C, Wang, Z, Zhang, S, De Saeger, S, De Boevre, M. 2017

[2]Liquid Chromatography Quadrupole Time-Of-Flight Mass Spectrometry And Rapid Evaporative Ionization Mass Spectrometry Were Used To Develop A Lamb Authentication Method: A Preliminary Study. Wang, JS, Xu, L, Xu, ZZ, Wang, YY, Niu, CN, Yang, SM. 2020

[3]Development of a Method for the Determination of Rifaximin and Rifampicin Residues in Foods of Animal Origin. Li Ping Fan,Qi Tao,Xiao Qiao Wang,Xiao Hui Xu,Ya Jun Yang,Jian Yong Li. 2024

[4]Simultaneous determination of eight tetracyclines in cattle hair using UPLC-QTRAP/MS: A novel non-invasive strategy for veterinary drug residue. Zhanteng Song,Zhixin An,Maerhaba Paerhati,Adilitai Tielik,Jinrong Zhu,Gayna Serhali,Decheng Suo. 2025

作者其他论文 更多>>