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Covalent conjugation with quercetin mitigates allergenicity of the bee pollen allergen Bra c p in a murine model

文献类型： 外文期刊

作者： Zhou, Enning;Li, Qiangqiang;Xu, Rui;Pan, Fei;Tao, Yuxiao;Li, Xiangxin;Xue, Xiaofeng;Wu, Liming

作者机构：

关键词： Bra c p;Quercetin;Covalent conjunction;Allergenicity;Purine metabolism;Calcium signaling

期刊名称： FOOD CHEMISTRY

ISSN： 0308-8146

年卷期： 2024 年 436 卷

页码：

收录情况： SCIE（2024版） ; ; EI（2024版）

摘要： Profilin family members are highly conserved food allergens that can cause widespread cross-allergic reactions. Our previous research has demonstrated that the covalent conjunction with quercetin can disrupt the conformational epitopes of a profilin allergen, Bra c p. In this study, we further investigated the intrinsic molecular mechanisms using molecular dynamics simulations. Moreover, the allergenic potential of Bra c p and its conjugate with quercetin was assessed in BALB/c mice. The results showed that continuous interaction with quercetin increased the molecular motion of Bra c p, causing changes to its alpha-helices and exposing hydrophobic residues which altered antigenic epitopes. Additionally, mice treated with Bra c p-quercetin conjugate showed reduced allergic reactions compared to those treated with Bra c p alone by regulating purine metabolism, calcium signaling, and CD4+CD25+ Tregs proportion. Quercetin conjugation decreases the allergenicity of Bra c p, providing a scientific foundation for reducing the profilin allergens in food.

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