数字农科院2.0

Upregulation of NbUBP16 induced by rice stripe virus infection stabilizes NbSHMT1 to suppresses ROS accumulation and facilitate virus infection

文献类型： 外文期刊

作者： 王坤;;;;王亚琴;;;;傅帅;;;;谭羽翀;;;;Liang Wu;;;;徐毅;;;;吴建祥;;;;周雪平

关键词： Rice stripe virus; NbUBP16; Ubiquitination; SHMT1; ROS accumulation

期刊名称： Stress Biology

ISSN： 2097-4418

年卷期： 2025 年

页码：

收录情况： CSCD（2025-2026年度） ; ; ESCI（2025版）

摘要： Modification of proteins by ubiquitin is a dynamic and reversible process. It is unclear whether rice stripe virus (RSV) can modulate the plant deubiquitination pathway. In this study, we found that RSV infection can specifically upregulate the expression of the deubiquitinase NbUBP16. Further analysis revealed that NbUBP16 stabilizes serine hydroxymethyltrasferase (SHMT1) by binding to NbSHMT1 and removing its polyubiquitination modification mediated by E3 ligase MEL, which inhibits downstream SHMT1-mediated ROS accumulation and thereby facilitates RSV infection. Our findings provide new insights into the molecular arms race between pathogens and plants, demonstrating how a plant virus can undermine plant defenses by hijacking host deubiquitination pathways.

分类号：

  • 相关文献

[1]Ubiquitination of susceptibility proteins modulates rice broad-spectrum resistance. Wang R., Xu X., Wang G.-L., Ning Y.. 2022

[2]Chitosan Oligosaccharides Induce Apoptosis In H.uman Renal Carcinoma Via R eactive-Oxygen-Species-Dependent Endoplasmic Reticulum Stress. Zhai, XC, Yuan, SJ, Yang, X, Zou, P, Li, LN, Li, GY, Shao, Y, Abd El-Aty, AM, Hacimuftuoglu, A, Wang, J. 2019

[3]Ascorbic acid modulation by ABI4 transcriptional repression of VTC2 in the salt tolerance of Arabidopsis. Xiamusiya Kakan,Yanwen Yu,Shenghui Li,Xiaoying Li,Rongfeng Huang,王娟. 2021

[4]A Novel Aspartic Protease Inhibitor Inhibits The Enzymatic Browning Of Potatoes. Dong, TT, Cao, Y, Li, GC, Zhu, ZR, Zhang, S, Jiang, CZ, Wang, QG. 2021

[5]Detection and fine mapping of two quantitative trait loci for partial resistance to stripe virus in rice (Oryza sativa L.). Zhang, Ying-Xin,Wang, Qi,Jiang, Ling,Wang, Bao-Xiang,Liu, Ling-Long,Shen, Ying-Yue,Cheng, Xia-Nian,Wan, Jian-Min,Wan, Jian-Min.

[6]Whole Genome Deep Sequencing Revealed H.ost Impact On Population S tructure, Variation And Evolution Of Rice Stripe Virus. Zhou, Xueping,Liang, Jingting,Wu, Sanling,Jiang, Jun,Zhou, Xueping,Wu, Jianxiang,Lu, Lina. 2018

[7]Rice Stripe Virus Interferes With S.-Acylation Of Remorin And I nduces Its Autophagic Degradation To Facilitate Virus Infection. Zhou, Xueping,Zhou, Xueping,Xu, Yi,Xu, Yi,Wu, Jianxiang,Li, Yi,Li, Chenyang,Li, Chenyang,Fu, Shuai. 2018

[8]Nsvc4 encoded by rice stripe virus targets host chloroplasts to suppress chloroplast-mediated defense. Zongdi Li,Chenyang Li,Shuai Fu,Yu Liu,Yi Xu,Jianxiang Wu,Yaqin Wang,Xueping Zhou. 2022

[9]Comparative transcriptome analysis of chemoreception organs of laodelphax striatellus in response to rice stripe virus infection. Yao Li,Yunye Zhang,Yin Xiang,Danyu Chen,Jia Hu,Fang Liu. 2021

[10]The Vitellogenin Receptor Has An E.ssential Role In Vertical T ransmission Of Rice Stripe Virus During Oogenesis In The Small Brown Plant Hopper. Li, Fei,Lin, Kejian,He, Kang,He, Kang,Ding, Simin,He, Kang,Wang, Guirong. 2019

[11]Rice stripe virus: Exploring Molecular Weapons in the Arsenal of a Negative-Sense RNA Virus. Yi Xu,Shuai Fu,Xiaorong Tao,Xueping Zhou. 2021

[12]Rice stripe virus nonstructural protein 3 suppresses plant defence responses mediated by the MEL-SHMT1 module. Wang, Kun,Fu, Shuai,Wu, Liang,Wu, Jianxiang,Wang, Yaqin,Xu, Yi,Zhou, Xueping. 2023

[13]N6-methyladenosine modification of the mRNA for a key gene in purine nucleotide metabolism regulates virus proliferation in an insect vector. Zhu M.,Wu N.,Zhong J.,Chen C.,Liu W.,Ren Y.,Wang X.,Jin H.. 2024

[14]Upregulation of deubiquitinase UBP16 induced by rice stripe virus infection stabilizes SHMT1 to suppress ROS accumulation and facilitate virus infection in Nicotiana benthamiana. Kun Wang,Yaqin Wang,Shuai Fu,Yuchong Tan,Liang Wu,Yi Xu,Jianxiang Wu,Xueping Zhou. 2025

[15]Nitrogen Limitation Adaptation (Nla) Is I.nvolved In Source-To-Sink Remobilization O f Nitrate By Mediating The Degradation Of Nrt1.7 In Arabidopsis. Liu, WW, Sun, Q, Wang, K, Du, QG, Li, WX. 2017

[16]Proteomic Analysis Of Ubiquitinated Proteins I.n Rice (Oryza Sativa) A fter Treatment With Pathogen-Associated Molecular Pattern (Pamp) Elicitors. Chen, Xiao-Lin,Chen, Xiao-Lin,Liu, Caiyun,Liu, Wende,Luo, Feng,Xie, Xin,Wang, Guo-Liang,Wu, Liye,Wang, Guo-Liang,Zeng, Lirong,Zhou, Xueping. 2018

[17]Porcine Ring Finger Protein 114 I.nhibits Classical Swine Fever V irus Replication Via K27-Linked Polyubiquitination Of Viral Ns4B. Zhang, YX, Zhang, HW, Zheng, GL, Yang, Q, Yu, SX, Wang, JH, Li, S, Li, LF, Qiu, HJ. 2019

[18]The Xanthomonas Effector Xopk Harbours E.3 Ubiquitin-Ligase Activity That I s Required For Virulence. Zhou, Xiaogang,Zhou, Xiaogang,Yin, Junjie,Yang, Fan,Sun, Lifan,Wang, Kailun,Zhang, Jie,Chen, Xuewei,Qin, Jun,Liao, Haicheng,Rong, Wei,Chen, Huamin,Wang, Kailun. 2018

[19]Ring-Domain E3 Ligase-Mediated Host-Virus Interactions: O.rchestrating Immune Responses By T he Host And Antagonizing Immune Defense By Viruses. Zhang, YX, Li, LF, Munir, M, Qiu, HJ. 2018

[20]The E3 Ubiquitin Ligase Tbk1 Mediates The Degradation Of Multiple Picornavirus Vp3 Proteins By Phosphorylation And Ubiquitination. Li, D, Yang, WP, Ren, JJ, Ru, Y, Zhang, KS, Fu, SZ, Liu, XT, Zheng, HX. 2019

作者其他论文 更多>>