数字农科院2.0

A pathogen peptidoglycan scaffold coated with artificial biomembrane promotes broad resistance to bacterial infections by dynamically reprogramming macrophage metabolism

文献类型： 外文期刊

作者： Junjie Guo;Shuo Jia;Zibo Mai;Chaonan Wang;Zheng Jia;Jiaqing Wang;Xinran Yao;Jiaqi Liu;Fang Wang;Junwei Ge

作者机构：

关键词： Artificial biomembrane coating;Immune modulation;Metabolic reprogramming;MRSA;Trained immunity

期刊名称： Materials Today Bio

ISSN： 2590-0064

年卷期： 2025 年 35 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： The increasing severity of multidrug-resistant (MDR) bacteria and the shortage of effective treatment strategies urgently require the development of new immunotherapies to combat superbug infections. Trained immunity may offer a novel and effective mechanism to combat resistant superbugs. However, there are currently few materials capable of effectively activating trained immunity, highlighting the need for new agents that provide more durable protection. In this study, we developed a bacterium-like particle (BLP) based on protein-free artificial biomembrane coating immune activator, named LM@pBLP, which features a simple and rapid preparation process, excellent biocompatibility, long-term stability, and a cost-effective advantage. LM@pBLP trains the immune system to target a broad range of pathogens, offering rapid, broad-spectrum, and long-lasting protection against MDR infections. After stimulation with LM@pBLP, it activates glutathione metabolism and amino acid metabolism, induces macrophage metabolic and epigenetic reprogramming changes, and regulates phagocytosis and inflammatory responses to infection. Additionally, LM@pBLP regulates reactive oxygen species (ROS), thereby maintaining oxidative stress homeostasis. Our study demonstrates that LM@pBLP primarily provides rapid, broad-spectrum, and long-lasting protection for experimental animals by activating trained immunity, which opens a new avenue for addressing MDR infections.

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