数字农科院2.0

Akt-FoxO signaling drives co-adaptation to insecticide and host plant stresses in an herbivorous insect

文献类型： 外文期刊

作者： Zhang, Huihui;Gao, Haoli;Lin, Xumin;Yang, Baojun;Wang, Jingting;Yuan, Xiaowei;Zhang, Zhen;He, Tianshun;Liu, Zewen

作者机构：

关键词： Akt-FoxO signaling pathway;P450 monooxygenases;Host adaptation;Insecticide resistance;Co-adaptation

期刊名称： JOURNAL OF ADVANCED RESEARCH

ISSN： 2090-1232

年卷期： 2025 年 75 卷

页码：

收录情况： SCIE（2025版）

摘要： Introduction: Ongoing interactions between host and herbivorous insect trigger a co-evolutionary arms race. Genetic diversity within insects facilitates their adaptation to phytochemicals and their derivatives, including plant-derived insecticides. Cytochrome P450s play important roles in metabolizing phytochemicals and insecticides, due to their diversity and almost perfect evolution. Objectives: This study aims to uncover a common molecular mechanism in herbivorous insects by investigating the role of kinase-transcription factor regulation of P450s in conferring tolerance to both insecticides and phytochemicals. Methods: RNA interference, transcriptome sequencing, insecticide, and phytochemical bioassays were conducted to validate the functions of Akt, FoxO, and candidate P450s. Dual-luciferase activity assays were employed to identify the regulation of P450s by the Akt-FoxO signaling pathway. Recombinant P450 enzymes were utilized to investigate the metabolism of insecticides and phytochemicals. Results: We identified an Akt-FoxO signaling cascade, a representative of kinase-transcription factor pathways. This cascade mediates the expression of eight P450 enzymes involved in the metabolism of insecticides and phytochemicals in Nilaparvata lugens. These P450s are from different families and with different substrate selectivity, enabling them to respectively metabolize insecticides and phytochemicals with structure diversity. Nevertheless, the eight P450 genes were up-regulated by FoxO, which was inhibited in a higher cascade by Akt through phosphorylation. The discovery of the Akt-FoxO signaling pathway regulating a series of P450 genes elucidates the finely tuned regulatory mechanism in insects for adapting to phytochemicals and insecticides. Conclusion: These finding sheds light on the physiological balance maintained by these regulatory processes. The work provides the experimental evidence of co-adaptation to the stresses imposed by host plant and insecticide within the model of the kinase-TF involving various P450s. This model provides a comprehensive view of how pests adapt to multiple environmental stresses. (c) 2024 Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

分类号：

  • 相关文献

[1]Comparative genomic analysis of the IId subtype family of Cryptosporidium parvum. Feng, Yaoyu,Li, Na,Feng, Yaoyu,Liu, Guangyuan,Li, Na,Roellig, Dawn M.,Kelley, Alyssa,Amer, Said,Xiao, Lihua,Amer, Said,Xiao, Lihua,Zhang, Longxian.

[2]Genome of the Giant Panda Roundworm Illuminates Its Host Shift and Parasitic Adaptation. Yue Xie,Sen Wang,Shuangyang Wu,Shenghan Gao,Qingshu Meng,Chengdong Wang,Jingchao Lan,Li Luo,Xuan Zhou,Jing Xu,Xiaobin Gu,Ran He,Zijiang Yang,Xuerong Peng,Songnian Hu,Guangyou Yang. 2022

[3]Population genetics of the cereal cyst nematode Heterodera avenae reveal geographical segregation and host adaptation. Hudie Shao,Linfeng Zhu,Zhiqiang Li,Ru Jiang,Shiming Liu,Wenkun Huang,Chuanren Li,Ling an Kong,Deliang Peng,Huan Peng. 2023

[4]Pangenomic analysis of Wolbachia provides insight into the evolution of host adaptation and cytoplasmic incompatibility factor genes. Bo Liu,Ye Song Ren,Cheng Yuan Su,Yoshihisa Abe,Dao Hong Zhu. 2023

[5]Chromosome-level genome of black cutworm provides novel insights into polyphagy and seasonal migration in insects. Minghui Jin,Bo Liu,Weigang Zheng,Conghui Liu,Zhenxing Liu,Yuan He,Xiaokang Li,Chao Wu,Ping Wang,Kaiyu Liu,Shigang Wu,Hangwei Liu,Swapan Chakrabarty,Haibin Yuan,Kenneth Wilson,Kongming Wu,Wei Fan,Yutao Xiao. 2023

[6]Feeding experience on hairy vetch induces a loss of host-specific adaptation to maize and changes in the gut microbiota communities of the fall armyworm. Ma, Lin,Wang, Dao-Tong,Ren, Qi-Lin,Zhang, Lei,Cheng, Yun-Xia,Jiang, Xing-Fu. 2023

[7]Genome degradation promotes Salmonella pathoadaptation by remodeling fimbriae-mediated proinflammatory response. Xiao Zhou,Xiamei Kang,Jiaqi Chen,Yan Song,Chenghao Jia,Lin Teng,Yanting Tang,Zhijie Jiang,Xianqi Peng,Xiaoxi Tao,Yiwei Xu,Linlin Huang,Xuebin Xu,Yaohui Xu,Tengfei Zhang,Shenye Yu,Jiansen Gong,Shaohui Wang,Yuqing Liu,Guoqiang Zhu,Corinna Kehrenberg,François Xavier Weill,Paul Barrow,Yan Li,Guoping Zhao,Min Yue. 2023

[8]Gut Microbiota Affects Host Fitness of Fall Armyworm Feeding on Different Food Types. Lin Ma,Daotong Wang,Qilin Ren,Jiaqi Sun,Lei Zhang,Yunxia Cheng,Xingfu Jiang. 2024

[9]Genome-wide analyses of glutathione S-transferase gene family and expression profiling among three haplotypes Aphis gossypii. Yaling Zhang,Muhammad Farhan,Hanjing Yang,Jun Zhao,Xiaoyan Ma,Shuai Zhang. 2025

[10]Chromosome-level genome assembly of Dendrothrips minowai and genomic analysis highlights distinct adaptations to high polyphenols in tea plants. Xiu, Chunli,Zhao, Dehai,Zhang, Jiahui,Liu, Haitao,Wang, Yusheng,Liu, Hangwei,Cai, Xiaoming,Luo, Zongxiu,Bian, Lei,Fu, Nanxia,Zhou, Li,Chen, Zongmao,Li, Zhaoqun. 2025

[11]Integrated multiomics reveals host-virus coadaptation in persistent foot-and-mouth disease virus infection. Wang, Shuang,Zhang, Zhihui,Wei, Sumin,Huang, Guoliang,Yin, Shuanghui,Mu, Suyu,Dong, Hu,Sun, Shiqi,Guo, Huichen. 2025

[12]Evolutionary Dynamics of Codon Usage Bias in Tomato Spotted Wilt Virus: Insights into Viral Adaptation and Host Interactions. Haiting Zhao,Lang Qin,Xiaolong Deng,Stuart Reitz,Shengyong Wu,Zhen He. 2025

[13]Gene expression profiling in the thiamethoxam resistant and susceptible B-biotype sweetpotato whitefly, Bemisia tabaci. Zhou, Xu-guo,Xie, Wen,Yang, Xin,Wang, Shao-li,Wu, Qing-jun,Yang, Ni-na,Li, Ru-mei,Jiao, Xiao-guo,Pan, Hui-peng,Liu, Bai-ming,Feng, Yun-tao,Xu, Bao-yun,Zhang, You-jun. 2012

[14]Tebufenozide resistance is associated with sex-linked inheritance in Plutella xylostella. Han, Zhao-Jun,Cao, Guang-Chun. 2015

[15]Field resistance to spinosad in western flower thrips Frankliniella occidentalis (Thysanoptera: Thripidae). Lei Zhong-ren,Gao Yu-lin,Li Dong-gang,Shang Xiao-yong,Reitz, Stuart,Nauen, Ralf,Si Hyeock Lee. 2016

[16]Abamectin resistance in strains of vegetable leafminer, Liriomyza sativae (Diptera: Agromyzidae) is linked to elevated glutathione S-transferase activity. Lei, Zhong-Ren,Gao, Yu-Lin,Wei, Qing-Bo,Cai, Du-Cheng,Nauen, Ralf. 2015

[17]A 36-bp deletion in the alpha subunit of glutamate-gated chloride channel contributes to abamectin resistance in Plutella xylostella. Liu, Feng,Shi, Xiuzhen,Wu, Qingjun,Xu, Baoyun,Xie, Wen,Wang, Shaoli,Zhang, Youjun,Liang, Yanpo,Liu, Feng,Liu, Nannan.

[18]Point mutations in acetylcholinesterase 1 associated with chlorpyrifos resistance in the brown planthopper, Nilaparvata lugens Stal. Zhang, Y.,Yang, B.,Li, J.,Liu, M.,Liu, Z.,Yang, B..

[19]Sensitivity of Bemisia Tabaci (Hemiptera: Aleyrodidae) to Several New Insecticides in China: Effects of Insecticide Type and Whitefly Species, Strain, and Stage. Xie, Wen,Liu, Yang,Wang, Shaoli,Wu, Qingjun,Pan, Huipeng,Yang, Xin,Guo, Litao,Zhang, Youjun. 2014

[20]Environment polluting conventional chemical control compared to an environmentally friendly IPM approach for control of diamondback moth, Plutella xylostella (L.), in China: a review. Jin, Fengliang,Farooq, Muhammad,Nasim, Wajid,Nasim, Wajid,Nasim, Wajid,Akram, Waseem,Khan, Fawad Zafar Ahmad,Jaleel, Waqar,Zhu, Xun,Yin, Haichen,Fahad, Shah,Chauhan, Bhagirath Singh.

作者其他论文 更多>>