数字农科院2.0

Identification of circRNA-associated ceRNA networks in the longissimus dorsi of yak under different feeding systems

文献类型： 外文期刊

作者： Ma X.;Guo X.;Yongfu L.;Wang T.;Bao P.;Chu M.;Wu X.;Yan P.;Liang C.

作者机构：

关键词： ceRNA;circRNAs;Longissimus dorsi;Yak

期刊名称： BMC Veterinary Research

ISSN： 1746-6148

年卷期： 2024 年 20 卷 1 期

页码：

收录情况： SCIE（2024版）

摘要： Background: Yaks (Bos grunniens), prized for their ability to thrive in high-altitude environments, are indispensable livestock in the plateau region. Modifying their feeding systems holds significant promise for improving their growth and meat quality. Tenderness, a key determinant of yak meat quality and consumer appeal, is demonstrably influenced by dietary regimen. Indoor feeding regimes have been shown to enhance tenderness by lowering shear stress and optimizing pH values. CircRNAs, well-known modulators of circulatory function, also play a crucial role in skeletal muscle development across various animal species. However, their functional significance in yak skeletal muscle remains largely unexplored. Results: In this study, we identified a total of 5,534 circRNAs within the longissimus dorsi muscle, and we found 51 differentially expressed circRNAs (20 up-regulated and 31 down-regulated) between the two feeding groups. Constructing a comprehensive ceRNA network illuminated intricate regulatory mechanisms, with PGP and circRNA_0617 converging on bta-miR-2285q, mirrored by KLF15/circRNA_0345/bta-miR-20b and CTSF/circRNA_0348/bta-miR-146a. These findings shed light on the potential of circRNAs to influence yak muscle development and meat quality, offering valuable insights for future research. Conclusions: This investigation unraveled a complex interaction network between circRNAs、mRNAs and miRNAs in yak skeletal muscle. We further elucidated the target genes regulated by these target genes within the network, offering valuable insights into the potential regulatory mechanisms governing muscle development and meat quality-related traits in yaks. © The Author(s) 2024.

分类号：

  • 相关文献

[1]Regulatory Role of N6-Methyladenosine in Longissimus Dorsi Development in Yak. Xiaoming Ma,Yongfu La,Pengjia Bao,Min Chu,Xian Guo,Xiaoyun Wu,Jie Pei,Xuezhi Ding,Chunnian Liang,Ping Yan. 2022

[2]Full-length transcriptome sequencing of the longissimus dorsi muscle of yak and cattle-yak using nanopore technology. Cao, Mengli,Ding, Ziqiang,Wang, Xingdong,Guo, Shaoke,Kang, Yandong,Hu, Liyan,Zhang, Ben,Pei, Jie,Ma, Yi,Guo, Xian. 2025

[3]Whole-transcriptome sequencing analysis to identify key circRNAs, miRNAs, and mRNAs in the development of yak testes. Liyan Hu,Xingdong Wang,Shaoke Guo,Mengli Cao,Yandong Kang,Ziqiang Ding,Jie Pei,Qianyun Ge,Yi Ma,Xian Guo. 2024

[4]Identification and Analysis of Circular RNAs in Mammary Gland from Yaks Between Lactation and Dry Period. Yilin Shi,Xiaoyun Wu,Guangyao Meng,Xiaoming Ma,Yongfu La,Pengjia Bao,Min Chu,Ping Yan. 2025

[5]环状RNA及其在生态毒理学研究中的应用进展. 王瑞,李亮. 2021

[6]“大通”牦牛Lfcin基因克隆及生物信息学分析(英文). 裴杰,阎萍,姬国红,冯瑞林,梁春年,郭宪,曾玉峰,包鹏甲,褚敏. 2009

[7]多房棘球蚴诱导小鼠枯否氏细胞极化相关ceRNA调控网络的构建与分析. 李艳萍,刘婷丽,李红,陈国梁,王立群,郭小腊,骆学农. 2022

[8]Genes Expression Related to Intramuscular Fat Deposition in Muscles of Small Tail Han Sheep. Liu, Yan,Ma, Teng,Du, Weihua,Hao, Haisheng,Wang, Dong,Zhao, Xueming,Li, Haijing,Jiang, Qiuling,Zhu, Huabin. 2012

[9]Effects of Coconut Oil and Palm Oil on Growth, Rumen Microbiota, and Fatty Acid Profile of Suckling Calves. Fengming Hu,Minyu Piao,Chuntao Yang,Qiyu Diao,Yan Tu. 2023

[10]Estrogen-mediated oar-miR-485-5p targets PPP1R13B to regulate myoblast proliferation in sheep. Siqi Liu,Ziyi Liu,Peng Wang,Wentao Li,Shengguo Zhao,Yufang Liu,Mingxing Chu. 2023

[11]Transcriptome-Metabolome Analysis Reveals That Crossbreeding Improves Meat Quality in Hu Sheep and Their F1-Generation Sheep. Zhang, Liwa,An, Xuejiao,Xu, Zhenfei,Niu, Chune,Geng, Zhiguang,Zhang, Jinxia,Shi, Haina,Chen, Zhenghan,Zhang, Rui,Yue, Yaojing. 2025

[12]Integrated proteomics and metabolomics elucidate HSD17B12 regulation of intramuscular fat deposition for enhanced beef quality. Yuan Liu,Shuang Liu,Xue Feng,Mengli Yang,Xue Bai,Dawei Wei,Bei Cai,Runjun Yang,Lupei Zhang,Yun Ma. 2025

[13]Genome-wide profiling of Sus scrofa circular RNAs across nine organs and three developmental stages. Liang, Guoming,Yang, Yalan,Niu, Guanglin,Tang, Zhonglin,Li, Kui,Liang, Guoming,Yang, Yalan,Tang, Zhonglin,Li, Kui,Liang, Guoming,Yang, Yalan,Tang, Zhonglin.

[14]Genome-Wide Profiling Of Sus Scrofa C.ircular Rnas Across Nine O rgans And Three Developmental Stages. Liang, GM, Yang, YL, Niu, GL, Tang, ZL, Li, K. 2017

[15]Circular RNA transcriptome across multiple tissues reveal skeletal muscle-specific circPSME4 regulating myogenesis. Mu Zeng,Shanying Yan,Peng Yang,Qiaowei Li,Jiju Li,Xinhao Fan,Xiaoqin Liu,Yilong Yao,Wei Wang,Ruipu Chen,Guohao Han,Yalan Yang,Zhonglin Tang. 2023

[16]Identification of circRNAs Associated with Adipogenesis Based on RNA-seq Data in Pigs. Li Q.,Wang L.,Xing K.,Yang Y.,Abiola Adetula A.,Liu Y.,Yi G.,Zhang H.,Sweeney T.,Tang Z.. 2022

[17]Genome-wide expression profiling of mrnas, lncrnas and circrnas in skeletal muscle of two different pig breeds. Hou X.,Wang L.,Zhao F.,Zhang L.,Liu X.,Gao H.,Shi L.,Yan H.,Wang L.. 2021

[18]Recent Progress on Circular RNAs in the Development of Skeletal Muscle and Adipose Tissues of Farm Animals. Shanying Yan,Yangli Pei,Jiju Li,Zhonglin Tang,Yalan Yang. 2023

[19]Genome-wide identification and functional prediction of circular RNAs in response to heat stress in Chinese Holstein cows. Ying Qi,Lin Zhang,Yuemei Guo,Jing Wang,Mingxing Chu,Yiming Zhang,Junfei Guo,Qiuling Li. 2021

[20]Analyses of circRNAs profiles of the lactating and nonlactating crops in pigeon (Columba livia). Ma H.,Bian S.,Li Y.,Ni A.,Zhang R.,Ge P.,Han P.,Wang Y.,Zhao J.,Zong Y.,Yuan J.,Sun Y.,Chen J.. 2023

作者其他论文 更多>>