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Temperature modulation by bacterial communities may shape the MGE-mediated spread of ARGs during composting of gentamicin fermentation residue

文献类型： 外文期刊

作者： Yuanwang Liu;Ruiyan He;Minmin Feng;Deling Yuan;Zhaojun Li

作者机构：

关键词： Antibiotic fermentation residue;Bacterial diversity;Mobile genetic element;Partial least squares path model;Swine manure

期刊名称： Journal of Environmental Management

ISSN： 0301-4797

年卷期： 2025 年 396 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： This study investigated the co-composting of press-dehydrated gentamicin fermentation residue (GFR) with swine manure to address the challenges posed by antibiotic fermentation residues, such as high residual antibiotic concentrations and the spread of antibiotic resistance genes (ARGs). The results demonstrated that composting could effectively remove gentamicin residues with removal rates up to 96.89 %. However, The absolute abundance of ARGs increased by 5.8- and 6.2-fold in the GPS and GS treatments, respectively, by the end of composting, suggesting their high persistence in composting environments. Swine manure, which had higher bacterial abundance and diversity than GFR, substantially shaped the initial ARG profiles in the composting treatments. Furthermore, partial least squares path model (PLS-PM) indicated that the sharp increase of ARGs after composting was significantly influenced by horizontal gene transfer mediated by MGEs, with integrons and plasmids playing a crucial role in their dissemination. Temperature was identified as a key factor affecting ARGs abundance by regulating the abundance or activity of MGEs. These results, in conjunction with the bacteria and ARG relationship, indicate that temperature dynamics shaped by microbial community succession may be a stronger driver of ARG dissemination than the role of bacteria as passive hosts, particularly for MGE-associated genes. This study highlights the significance of future research into strategies aimed at curbing the dissemination of ARGs across diverse settings, particularly by examining the expression patterns of MGEs under varying temperature conditions.

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