数字农科院2.0

Heat-Inactivated Lactiplantibacillus plantarum FRT4 Alleviates Diet-Induced Obesity via Gut-Liver Axis Reprogramming

文献类型： 外文期刊

作者： Huang, Yuyin;Wang, Qingya;Han, Xiling;Meng, Kun;Liu, Guohua;Zhang, Haiou;Zhang, Rui;Cai, Hongying;Yang, Peilong

作者机构：

关键词： Lactiplantibacillus plantarum FRT4;heat-inactivated probiotics;obesity;gut-liver axis;short-chain fatty acids;lipid metabolism

期刊名称： FOODS

ISSN：

年卷期： 2025 年 14 卷 16 期

页码：

收录情况： SCIE（2025版）

摘要： Obesity and related metabolic disorders are major global health challenges. Postbiotics, such as heat-inactivated probiotics, have attracted attention for their improved safety, stability, and potential metabolic benefits compared to live probiotics. However, the comparative anti-obesity effects and mechanisms of live versus heat-inactivated Lactiplantibacillus plantarum FRT4 remain unclear, so this study systematically evaluated their effects and mechanisms in high-fat-diet-induced obese mice. Mice received oral administration of live or heat-inactivated FRT4 (prepared by heating in a water bath at 80 degrees C for 5 min) for 16 weeks. Comprehensive analyses included metabolic profiling, histological evaluation, serum and liver biomarkers, gut microbiota composition, liver metabolomics, and transcriptomics. Both live and inactivated FRT4 significantly reduced body weight gain, adiposity, hepatic steatosis, and dyslipidemia, with inactivated FRT4 exhibiting comparable or superior efficacy. Notably, inactivated FRT4 restored gut microbiota composition, increased short-chain fatty acid production, and regulated hepatic metabolic pathways. Multi-omics analyses revealed modulation of lipid biosynthesis, amino acid metabolism, and energy utilization pathways. Specifically, the biosynthesis of unsaturated fatty acids pathway was downregulated in metabolomics and significantly enriched in transcriptomics, highlighting its central role in FRT4M-mediated metabolic reprogramming. These findings demonstrate that heat-inactivated Lp. plantarum FRT4 exerts systemic anti-obesity effects via gut-liver axis modulation, supporting its potential as a promising postbiotic intervention for obesity and metabolic dysfunction.

分类号：

  • 相关文献

[1]Lactiplantibacillus plantarum FRT4 attenuates high-energy low-protein diet-induced fatty liver hemorrhage syndrome in laying hens through regulating gut-liver axis. Li D.,Cai H.,Liu G.,Han Y.,Qiu K.,Liu W.,Meng K.,Yang P.. 2024

[2]Effects of inactivated Bacillus sp. DU-106 on high-fat diet-induced obesity and the gut-liver axis. Li, Yanli,Zhao, Wenjun,Jiang, Bingyan,Huang, Xiao-Chun,Liu, Jie,Huang, Junyuan,Hu, Bang,Liu, Yong-Xin,Du, Bing,Li, Pan. 2025

[3]Intestinal dysbiosis in nonalcoholic fatty liver disease (NAFLD): focusing on the gut-liver axis. Han, Hui,Jiang, Yi,Wang, Mengyu,Melaku, Mebratu,Liu, Lei,Zhao, Yong,Everaert, Nadia,Yi, Bao,Zhang, Hongfu. 2021

[4]Potato Resistant Starch Type 1 Promotes Obesity Linked with Modified Gut Microbiota in High-Fat Diet-Fed Mice. Zhang W.,Zhang N.,Guo X.,Fan B.,Cheng S.,Wang F.. 2024

[5]Mulberry branch fiber improved lipid metabolism and egg yolk fatty acid composition of laying hens via the enterohepatic axis. Hu H.,Li A.,Shi C.,Chen L.,Zhao Z.,Yin X.,Zhang Q.,Huang Y.,Pan H.. 2024

[6]Editorial: Natural polyphenols and metabolic syndrome. Zhang J.,Deng J.,Yang H.. 2023

[7]Fermented fruits ameliorate obesity by controlling food intake and regulating lipid metabolism in high-fat dietary mice. Tian Y.,Li F.,Du L.,Peng D.,Yang Z.,Li J.,Zhang J.. 2024

[8]牛FTO基因功能结构生物信息学分析. 刘建,阎萍,梁春年,郭宪,包鹏甲,裴杰,丁学智,褚敏,吴晓云,焦斐. 2011

[9]Lactiplantibacillus plantarum FRT4 protects against fatty liver hemorrhage syndrome: regulating gut microbiota and FoxO/TLR-4/NF-κB signaling pathway in laying hens. Daojie Li,Kun Meng,Guohua Liu,Zhiguo Wen,Yunsheng Han,Weiwei Liu,Xin Xu,Liye Song,Hongying Cai,Peilong Yang. 2025

[10]Whole Genome Sequencing and Extracellular Metabolite Profiling of Lactiplantibacillus plantarum FRT4: Insights into Probiotic Functionality. Yuyin Huang,Kun Meng,Guohua Liu,Zhimin Chen,Yunsheng Han,Peilong Yang,Rui Zhang,Hongying Cai. 2025

[11]Baicalin Alleviates Short-Term Lincomycin-Induced Intestinal and Liver Injury and Inflammation in Infant Mice. Zhang, Shunfen,Zhong, Ruqing,Tang, Shanlong,Han, Hui,Chen, Liang,Zhang, Hongfu. 2022

[12]Dietary fiber-derived short-chain fatty acids: A potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease. Shumin Zhang,Jingwen Zhao,Fei Xie,Hengxun He,Lee J. Johnston,Xiaofeng Dai,Chaodong Wu,Xi Ma. 2021

[13]Phlorizin Alleviates Inflammation Caused by Deoxynivalenol by Regulating the Gut Microbiome and Inhibiting the TLR4/MyD88/NF-κB Signaling Pathway in Mice. Zhao T.,Jin J.,Huangfu B.,He X.,Zhang B.,Li X.,Xu W.,Xing F.. 2024

[14]Synergistic risk in the gut and liver: Insights into the toxic mechanisms and molecular interactions of combined exposure to triazophos and fenvalerate in zebrafish. Xuehua An,Ruike Wang,Chong Cao,Dou Wang,Chen Chen,Yanhua Wang. 2024

[15]Decoding the role of the intestinal epithelium in hepatitis E virus infection using a human organoid prototype of “gut-liver” axis. Kuan Liu,Yang Wang,Jiangrong Zhou,Joy Joàn van der Meij,Luc J.W. van der Laan,Pengfei Li,Qiuwei Pan. 2025

[16]Metabolite-mediated crosstalk: unraveling the interactions between gut microbiota and host in fatty liver hemorrhagic syndrome of laying hens. Shaobo Zhang,Xinghua Zhao,Xin He,Wanyu Shi,Ning Ma. 2026

[17]Nettle (Urtica cannabina L.) polysaccharides as a novel dietary supplement: enhancing systemic antioxidant status via modulation of the gut-liver axis. Zhang, Jize,Zhang, Qian,Zhang, Xiaoqing,Qiao, Jiang,Wang, Jingwei,Gao, Yang,Dong, Ping. 2025

[18]Effects of dietary hull-less barley beta-glucan on the cholesterol metabolism of hypercholesterolemic hamsters. Tong, Li-Tao,Zhong, Kui,Liu, Liya,Zhou, Xianrong,Zhou, Sumei,Qiu, Ju.

[19]Effects of dietary wheat bran arabinoxylans on cholesterol metabolism of hypercholesterolemic hamsters. Tong, Li-Tao,Zhong, Kui,Liu, Liya,Guo, Lina,Zhou, Xianrong,Zhou, Sumei,Qiu, Ju,Cao, Li,Cao, Li.

[20]Effects of Bacillus subtilis BSNK-5-Fermented Soymilk on the Gut Microbiota by In Vitro Fecal Fermentation. Yaxin Gao,Lizhen Hou,Miao Hu,Danfeng Li,Zhiliang Tian,Wei Wen,Bei Fan,Shuying Li,Fengzhong Wang. 2022

作者其他论文 更多>>