数字农科院2.0

Engineering plants using diverse CRISPR-associated proteins and deregulation of genome-edited crops

文献类型： 外文期刊

作者： Zaman, Qamar U.;Raza, Ali;Lozano-Juste, Jorge;Chao, Li;Jones, Michael G. K.;Wang, Hua-Feng;Varshney, Rajeev K.

作者机构：

关键词： CRISPR-system;; genome-edited crops;; CRISPR proteins;; Cas9;; dCas9;; Cas12a/Cpf1;; Cas13a/C2c2;; certification for deregulations

期刊名称： TRENDS IN BIOTECHNOLOGY

ISSN： 0167-7799

年卷期： 2024 年 42 卷 5 期

页码：

收录情况： SCIE（2024版） ; ; EI（2024版）

摘要： The CRISPR/Cas system comprises RNA -guided nucleases, the target specificity of which is directed by Watson-Crick base pairing of target loci with single guide (sg)RNA to induce the desired edits. CRISPR-associated proteins and other engineered nucleases are opening new avenues of research in crops to induce heritable mutations. Here, we review the diversity of CRISPR-associated proteins and strategies to deregulate genome-edited (GEd) crops by considering them to be close to natural processes. This technology ensures yield without penalties, advances plant breeding, and guarantees manipulation of the genome for desirable traits. DNA -free and off -target -free GEd crops with defined characteristics can help to achieve sustainable global food security under a changing climate, but need alignment of international regulations to operate in existing supply chains.

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