数字农科院2.0

A novel electrochemiluminescence immunosensor by the metal polydopamine framework mediating ultrasensitive dual-mode quenching for the detection of zearalenone in food

文献类型： 外文期刊

作者： Lingya Ning;Jiamin Wang;Ming Yu、王俊英、Junping Wang

作者机构：

关键词： Electrochemiluminescence immunosensor;Metal polydopamine framework;Quantum dots;Zearalenone

期刊名称： Sensors and Actuators B: Chemical

ISSN： 0925-4005

年卷期： 2025 年 446 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： A quenched electrochemiluminescence (ECL) immunosensor based on metal polydopamine framework (MPF) was proposed for zearalenone (ZEN) assay by using the reduced carboxylated graphene oxide (rGO-COOH) film with high conductivity and CeO2 nanorods (CeO2 NRs) as a co-reactant accelerator to synergistically amplify the ECL signal of SnS2 QDs. Since the ECL emission spectrum of SnS2 QDs partially overlapped with the ultraviolet absorption spectrum of MPF, energy resonance transfer occurred between SnS2 QDs (donor) and MPF (receptor), causing the quenching of ECL signal. At the same time, the surface of MPF contained abundant polydopamine (PDA), which had a strong scavenging effect on free radicals, further triggering the ECL signal quenching. The dual-mode quenching effect of MPF significantly improved the sensitivity of the ECL sensor. Under the optimal conditions, the developed sensor exhibited exceptional quantitative detection of ZEN across a wide linear detection range of 0.001 − 500 ng/mL, with a low detection limit of 1.03 × 10−4 ng/mL. Furthermore, the immunosensor yielded satisfactory results in practical sample applications. This work provides a novel approach for detecting of ZEN and broadens the application of metal-organic framework-derived materials.

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