数字农科院2.0

High Expression Level of α2-3-Linked Sialic Acids on Salivary Glycoproteins of Breastfeeding Women May Help to Protect Them from Avian Influenza Virus Infection

文献类型： 外文期刊

作者： Li Ding;Yimin Cheng;Wei Guo;Siyue Sun;Xiangqin Chen;Tiantian Zhang;Hongwei Cheng;Jiayue Hao;Yunhua Lu;Xiurong Wang;Zheng Li

作者机构：

关键词： avian influenza virus (AIV);breastfeeding women;glycoprotein;saliva;sialic acids (Sia)

期刊名称： Molecules

ISSN： 1420-3049

年卷期： 2022 年 27.0 卷 13 期

页码：

摘要： Terminal sialic acids (Sia) on soluble glycoprotein of saliva play an important role in the clearance of influenza virus. The aim of this study is to investigate the alteration of sialylation on the salivary proteins of women during the lactation period and its effect on the saliva binding ability to virus. In total, 210 saliva samples from postpartum women with and without breastfeeding were collected, and the expression level of α2-3/6-linked Sia on the whole salivary proteins and specific glycoproteins of IgA and MUC5B from different groups were tested and verified using lectin microarray, blotting analysis and ELISA based method. The H1N1 vaccine and three strains of Avian influenza virus (AIV) were used for the saliva binding assay. Results showed that the variation in salivary expression level of α2-3-linked Sia was much more obvious than the α2-6-linked Sia, which was up-regulated significantly in the breastfeeding groups compared to the non-breastfeeding groups at the same postpartum stage. Furthermore, the binding abilities of salivary glycoproteins to AIV strains and H1N1 vaccine were increased in breastfeeding groups accordingly. This finding adds new evidence for the maternal benefit of breastfeeding and provides new thinking to protect postpartum women from AIV infection.

分类号：

  • 相关文献

[1]Development Of A Reverse-Transcription Loop-Mediated I.sothermal Amplification Assay To D etect Avian Influenza Viruses In Clinical Specimens. Shi, L, Yu, XW, Yao, W, Yu, BL, He, LK, Gao, Y, Zhang, YX, Tian, GB, Ping, JH, Wang, XR. 2019

[2]Pregnancy-associated decrease of Siaα2-3Gal-linked glycans on salivary glycoproteins affects their binding ability to avian influenza virus. Li Ding,Xinle Fu,Wei Guo,Yimin Cheng,Xiangqin Chen,Kun Zhang,Guang Zhu,Fuying Yang,Hanjie Yu,Zhuo Chen,Xilong Wang,Xiurong Wang,Xiaohong Wang,Zheng Li. 2021

[3]Genetic characterization and receptor binding analysis of a novel H5N1 HPAI virus with a H6Nx-derived PA gene in Guangdong, China. Jieheng He,Jing Liu,Zhanfei Yan,Gaojie Chen,Runzhi Liu,Yu Yang,Yulin Yan,Sheng Yuan,Jinyue Guo,Yong Li,Hai Yu,Zhaoping Liang,Tao Ren,Shujian Huang,Feng Wen. 2024

[4]Host plant effects on alkaline phosphatase activity in the whiteflies, Bemisia tabaci Biotype B and Trialeurodes vaporariorum. Peng, Lu,Liu, Wan-Xue,Wan, Fang-Hao,Peng, Lu,Harris, Marvin K.. 2011

[5]Identification, comparison, and functional analysis of salivary phenol-oxidizing enzymes in Bemisia tabaci B and Trialeurodes vaporariorum. Peng, Lu,Yan, Ying,Yang, Chun Hong,Wan, Fang Hao,Peng, Lu,De Barro, Paul J.. 2013

[6]Mechanistic understanding of N-glycosylation in Ebola virus glycoprotein maturation and function. Wang, Bin,Wang, Yujie,Yao, Xiaoyu,Hu, Dan,Zhang, Zhuo,Zheng, Yong-Hui,Liu, Chaonan,Zheng, Shimin,Xiang, Shi-Hua,Xiang, Shi-Hua,Zheng, Yong-Hui.

[7]Simultaneous Determination of 14 Kinds of beta-Agonist Residues in Sheep Saliva by Ultra Performance Liquid Chramatogrephy-Tandem Mass Spectrometry. Li Yang,Su Xiao-Ou,Wang Rui-Guo,Wang Pei-Long,Zhang Wei,Chen Jie. 2013

[8]Newcastle disease virus-vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs. Kong, Dongni,Wen, Zhiyuan,Su, Hua,Ge, Jinying,Chen, Weiye,Wang, Xijun,Wu, Chao,Chen, Hualan,Bu, Zhigao,Kong, Dongni,Wen, Zhiyuan,Su, Hua,Ge, Jinying,Chen, Weiye,Wang, Xijun,Wu, Chao,Chen, Hualan,Bu, Zhigao,Kong, Dongni,Yang, Chinglai.

[9]Protective efficacy of a recombinant Newcastle disease virus expressing glycoprotein of vesicular stomatitis virus in mice. Zhang, Minmin,Ge, Jinying,Li, Xiaofang,Chen, Weiye,Wang, Xijun,Wen, Zhiyuan,Bu, Zhigao. 2016

[10]HIV-1 Vpr increases Env expression by preventing Env from endoplasmic reticulum-associated protein degradation (ERAD). Zhang, Xianfeng,Zhou, Tao,Zheng, Yong-Hui,Zhang, Xianfeng,Zhou, Tao,Frabutt, Dylan A.,Zheng, Yong-Hui.

[11]Age- and sex-associated differences in the glycopatterns of human salivary glycoproteins and their roles against influenza A virus. Qin, Yannan,Zhong, Yaogang,Zhu, Minzhi,Dang, Liuyi,Yu, Hanjie,Chen, Zhuo,Chen, Wentian,Li, Zheng,Wang, Xiurong,Zhang, Hua.

[12]Recombinant lentogenic Newcastle disease virus expressing Ebola virus GP infects cells independently of exogenous trypsin and uses macropinocytosis as the major pathway for cell entry. Wen, Zhiyuan,Zhao, Bolin,Song, Kun,Hu, Xule,Chen, Weiye,Kong, Dongni,Ge, Jinying,Bu, Zhigao. 2013

[13]Recombinant adeno-associated virus serotype 9 AAV-RABVG expressing a Rabies Virus G protein confers long-lasting immune responses in mice and non-human primates. Shi, Chenjuan,Tian, Li,Zheng, Wenwen,Zhu, Yelei,Sun, Peilu,Liu, Lele,Liu, Wenkai,Song, Yanyan,Xia, Xianzhu,Xue, Xianghong,Zheng, Xuexing. 2022

[14]The effect of leafhopper saliva on volatiles in the processing of beauty tea. Jiawei Yan,Yuanchao Li,Lingling Ruan,Yunzhi Zhang,Chunmei He,Lei Bian,Zongxiu Luo,Zhaoqun Li,Naixing Ye,Yun Sun,Zongmao Chen,Xiaoming Cai,Shan Jin. 2025

作者其他论文 更多>>