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Anti-Inflammatory and Antidiarrheal Effects of Two Strains of Lactic Acid Bacteria Isolated from Healthy Pets on Escherichia coli K88-Induced Diarrhea in Mice

文献类型： 外文期刊

作者： Ya Zhao;Shukun Liang;Xiaoxin Fu;Yaping Guo;Yu Wang;Jiaxue Wang;Xiumin Wang;Zhenlong Wang;Hui Tao;Bing Han;Jinquan Wang

作者机构：

关键词： 16S rDNA;diarrhea;inflammation;Lacticplantibacillus plantarum;LimosiLactobacillus reuteri;pathway

期刊名称： Microorganisms

ISSN： 2076-2607

年卷期： 2025 年 13 卷 2 期

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收录情况： SCIE（2025版）

摘要： Lactic acid bacteria play a crucial role in maintaining the health of the host’s gut microbiota. In this study, the anti-inflammatory properties of Limosilactobacillus reuteri LR20-6 and Lacticplantibacillus plantarum L272 were evaluated using a mouse model of diarrhea induced by Escherichia coli. We also investigated their effects on gut microbiota regulation. The results indicated that both Lacticplantibacillus plantarum and Limosilactobacillus reuteri could reduce inflammation by inhibiting the expression of inflammatory factors IL-6 and TNF-α and blocking the MyD88 and NF-kB/p65 signaling pathways. Additionally, after intervention with these strains, the relative abundance of Lactobacillus was significantly increased. This suggested that Lacticplantibacillus plantarum and Limosilactobacillus reuteri could mitigate the severity of E. coli-induced diarrhea and enhance the abundance of beneficial probiotics in the gut of animals.

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