数字农科院2.0

MAPK pathway orchestrates gallid alphaherpesvirus 1 infection through the biphasic activation of MEK/ERK and p38 MAPK signaling

文献类型： 外文期刊

作者： Lu Cui;Xuefeng Li;Zheyi Liu;Xiaoxiao Liu;Yongxin Zhu;Yu Zhang;Zongxi Han;Yilei Zhang;Shengwang Liu;Hai Li

作者机构：

关键词： Apoptosis;Cell metabolism;Extracellular signal‐regulated kinase (ERK);Herpesvirus;Mitogen‐activated protein kinase (MAPK);p38 MAPK

期刊名称： Virology

ISSN： 0042-6822

年卷期： 2024 年 597 卷

页码：

收录情况： SCIE（2024版）

摘要： Therapies targeting virus-host interactions are seen as promising strategies for treating gallid alphaherpesvirus 1 (ILTV) infection. Our study revealed a biphasic activation of two MAPK cascade pathways, MEK/ERK and p38 MAPK, as a notably activated host molecular event in response to ILTV infection. It exhibits antiviral functions at different stages of infection. Initially, the MEK/ERK pathway is activated upon viral invasion, leading to a broad suppression of metabolic pathways crucial for ILTV replication, thereby inhibiting viral replication from the early stage of ILTV infection. As the viral replication progresses, the p38 MAPK pathway activates its downstream transcription factor, STAT1, further hindering viral replication. Interestingly, ILTV overcomes this biphasic antiviral barrier by hijacking host p38-AKT axis, which protects infected cells from the apoptosis induced by infection and establishes an intracellular equilibrium conducive to extensive ILTV replication. These insights could provide potential therapeutic targets for ILTV infection.

分类号：

  • 相关文献

[1]Potential Mechanisms Involved in Ceramide-induced Apoptosis in Human Colon Cancer HT29 Cells. Wang, Jing,Du, Yu-Guo,Lv, Xiao-Wen. 2009

[2]区分马流感和马鼻肺炎感染的分子生物学检测技术研究. 胡哲,初晓雨,常浩,王美月,李爽,王晓钧. 2015

[3]PRRSV强弱毒体外诱导IL-10产生差异的分子基础研究. 夏天奇,姜一峰,虞凌雪,周艳君,杨莘,高飞,李丽薇,曲泽慧,童光志. 2017

[4]PHD3 inhibits colon cancer cell metastasis through the occludin-p38 pathway. Yuyao Li,Tanglong Yuan,Hongwei Zhang,Shuting Liu,Jie Lun,Jing Guo,Yu Wang,Yuying Zhang,Jing Fang. 2023

[5]Isolation and characterization of a herpesvirus from feral pigeons in China. Zhao, Panpan,Ma, Jian,Guo, Ying,Tian, Li,Guo, Guangyang,Zhang, Kexin,Xing, Mingwei,Ma, Jian. 2015

[6]Crispr/Cas9-Mediated 2-Sgrna Cleavage Facilitates Pseudorabies V.irus Editing. Tang, YD, Guo, JC, Wang, TY, Zhao, K, Liu, JT, Gao, JC, Tian, ZJ, An, TQ, Cai, XH. 2018

[7]Application of CRISPR/Cas9 for Rapid Genome Editing of Pseudorabies Virus and Bovine Herpesvirus-1. Yu W.,Liu J.,Liu Y.,Forlenza M.,Chen H.. 2024

[8]MARCH1 and MARCH2 inhibit pseudorabies virus replication by trapping the viral cell-to-cell fusion complex in trans-Golgi network. Rui Huang,Cui Hong Rao,Yuan Zhe Bai,Changqing Yu,Meng Chen,Jin Mei Peng,Shi Jia Xu,Yue Sun,Meng Fandan,Chuang Lyu,Mirwaise Khan,Tong Qing An,Zhi Jun Tian,Xue Hui Cai,Gang Wang,Yan Dong Tang. 2024

[9]Characterization of thymus atrophy in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus. He, Yuli,Wang, Gang,Liu, Yonggang,Shi, Wenda,Han, Zifeng,Wu, Jianan,Jiang, Chenggang,Wang, Shujie,Hu, Shouping,Wen, Huiqiang,Dong, Jianguo,Liu, He,Cai, Xuehui. 2012

[10]Long-term High-fat High-sucrose Diet Promotes Enlarged Islets and beta-Cell Damage by Oxidative Stress in Bama Minipigs. Zhao, Zhan-zhao,Xin, Lei-lei,Xia, Ji-han,Yang, Shu-lin,Li, Kui,Zhao, Zhan-zhao,Chen, Yao-xing. 2015

[11]Construction of a mammalian cell expression vector pAcGFP-FasL and its expression in bovine follicular granulosa cells. Huang, Meng,Li, JunYa,Xu, ShangZhong,Yang, RunJun,Zhao, ZhiHui. 2011

[12]The non-structural (NS1) protein of influenza A virus associates with p53 and inhibits p53-mediated transcriptional activity and apoptosis. Wang, Xiaodu,Shen, Yang,Qiu, Yafeng,Shi, Zixue,Shao, Donghua,Chen, Peijun,Tong, Guangzhi,Ma, Zhiyong,Qiu, Yafeng,Shao, Donghua,Ma, Zhiyong. 2010

[13]Induction of apoptosis in HCT-116 colon cancer cells by polysaccharide of Larimichthys crocea swim bladder. Suo, Huayi,Xie, Jie,Song, Jia-Le,Song, Jia-Le,Yi, Ruokun,Zhou, Yalin,Zhu, Kai,Zhao, Xin,Liu, Zhenhu,Zhao, Xin. 2015

[14]The Apoptotic Effects of Alcohol Shock on Bovine Oocytes. Li, Xiangchen,Yao, Yaxin,Liu, Peng,Jin, Dapeng,Guan, Weijun,Yuehui, M. A.,Yao, Yaxin,Jin, Dapeng. 2011

[15]Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein. Fiedler, Nicola,Quant, Ellen,Fink, Ludger,Sun, Jianguang,Schuster, Ralph,Gerlich, Wolfram H.,Schaefer, Stephan. 2006

[16]The effects of IGF-1 on mouse spermatogenesis using an organ culture method. Yao, Jianfei,Gao, Jun,Wang, Mingming,Li, Xiangdong,Zuo, Haiyang,Wang, Dong.

[17]Cordyceps militaris polysaccharide triggers apoptosis and G(0)/G(1) cell arrest in cancer cells. Chen, Cheng,Wang, Mei-Lin,Jin, Chao,Chen, Hui-Juan,Li, Shao-Hui,Jia, Jun-Qiang,Gui, Zhong-Zheng,Li, Shu-Ying,Dou, Xing-Fan,Jia, Jun-Qiang,Gui, Zhong-Zheng. 2015

[18]Effects of camptothecin and hydroxycamptothecin on insect cell lines Sf21 and IOZCAS-Spex-II. Zhang, Lan,Zhang, Yanning,He, Weizhi,Ma, Dejun,Jiang, Hongyun. 2012

[19]Rhizoma smilacis glabrae protects rats with gentamicin-induced kidney injury from oxidative stress-induced apoptosis by inhibiting caspase-3 activation. Liu, Cuiyan,Kang, Youxi,Yang, Zisheng,Han, Chunyang,Zhou, Xiuhong,Gu, Jingang.

[20]Thapsigargin induces apoptosis when autophagy is inhibited in HepG2 cells and both processes are regulated by ROS-dependent pathway. Wang, Congcong,Tang, Shusheng,Zhao, Dongxu,Zhang, Chaoming,Zhang, Shen,Deng, Sijun,Zhou, Yan,Xiao, Xilong,Wang, Congcong,Li, Tao.

作者其他论文 更多>>