数字农科院2.0

Dynamic Variations in Endogenous Peptides in Chinese Human Milk Across Lactation and Geographical Regions

文献类型： 外文期刊

作者： Chen, Baorong;Li, Kaifeng;Wang, Xiaodan;Zhang, Wenyuan;Han, Sun;Zhang, Yumeng;Wang, Yunna;Pang, Xiaoyang;Xie, Qinggang;Lu, Jing;Jiang, Shilong;Zhang, Shuwen;Lv, Jiaping

作者机构：

关键词： human milk;endogenous peptides;lactation;Chinese cities;maternal diet

期刊名称： NUTRIENTS

ISSN：

年卷期： 2025 年 17 卷 19 期

页码：

收录情况： SCIE（2025版）

摘要： Background/Objectives: This study characterized the endogenous peptide profile of human milk from a Chinese multicenter cohort (n = 200 mothers) using the Orbitrap Fusion Lumos LC-MS/MS. Methods: Samples were collected across different lactation stages (2 and 6 months postpartum) and seven geographic regions (Beijing, Chengdu, Guangzhou, Jinhua, Lanzhou, Weihai, and Zhengzhou). Results: In total, 6960 peptides derived from 621 proteins were identified. Peptides from the polymeric immunoglobulin receptor (PIGR) were more abundant in the 2nd month than the 6th month, providing a high antimicrobial activity and immune functions for the infants. Moreover, region-specific variations were observed, with milk from Lanzhou exhibiting significantly higher levels of beta-casein (CASB) and butyrophilin subfamily 1 member A1 (BTN1A1) peptides compared to other cities. Conclusions: Furthermore, maternal dietary intake of oils and total fat correlated positively with the intensity of specific antimicrobial peptides, including CASB_199-216, CASB_200-226, and CASB_201-226. Infant growth parameters were inversely correlated with several antimicrobial peptides, although CASB_200-225 demonstrated positive associations. These findings offer novel insights into the dynamics of endogenous peptides in human milk and may guide breastfeeding recommendations and infant formula design.

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