数字农科院2.0

Global genetic diversity, introgression, and evolutionary adaptation of indicine cattle revealed by whole genome sequencing

文献类型： 外文期刊

作者： Ningbo Chen;Xiaoting Xia;Quratulain Hanif;Fengwei Zhang;Ruihua Dang;Bizhi Huang;Yang Lyu;Xiaoyu Luo;Hucai Zhang;Huixuan Yan;Shikang Wang;Fuwen Wang;Jialei Chen;Xiwen Guan;Yangkai Liu;Shuang Li;Liangliang Jin;Pengfei Wang;Luyang Sun;Jicai Zhang;Jianyong Liu;Kaixing Qu;Yanhong Cao;Junli Sun;Yuying Liao;Zhengzhong Xiao;Ming Cai;Lan Mu;Amam Zonaed Siddiki;Muhammad Asif;Shahid Mansoor;Masroor Ellahi Babar;Tanveer Hussain;Gamamada Liyanage Lalanie Pradeepa Silva;Neena Amatya Gorkhali;Endashaw Terefe;Gurja Belay;Abdulfatai Tijjani;Tsadkan Zegeye;Mebrate Genet Gebre;Yun Ma;Yu Wang;Yongzhen Huang;Xianyong Lan;Hong Chen;Nicola Rambaldi Migliore;Giulia Colombo;Ornella Semino;Alessandro Achilli;Mikkel Holger S. Sinding;Johannes A. Lenstra;Haijian Cheng;Wenfa Lu;Olivier Hanotte;Jianlin Han;Yu Jiang;Chuzhao Lei

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期刊名称： Nature Communications

ISSN： 2041-1723

年卷期： 2023 年 14 卷 1 期

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收录情况： SCIE（2023版）

摘要： Indicine cattle, also referred to as zebu (Bos taurus indicus), play a central role in pastoral communities across a wide range of agro-ecosystems, from extremely hot semiarid regions to hot humid tropical regions. However, their adaptive genetic changes following their dispersal into East Asia from the Indian subcontinent have remained poorly documented. Here, we characterize their global genetic diversity using high-quality whole-genome sequencing data from 354 indicine cattle of 57 breeds/populations, including major indicine phylogeographic groups worldwide. We reveal their probable migration into East Asia was along a coastal route rather than inland routes and we detected introgression from other bovine species. Genomic regions carrying morphology-, immune-, and heat-tolerance-related genes underwent divergent selection according to Asian agro-ecologies. We identify distinct sets of loci that contain promising candidate variants for adaptation to hot semi-arid and hot humid tropical ecosystems. Our results indicate that the rapid and successful adaptation of East Asian indicine cattle to hot humid environments was promoted by localized introgression from banteng and/or gaur. Our findings provide insights into the history and environmental adaptation of indicine cattle.

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