数字农科院2.0

Toxicokinetics and tissue-specific biotransformation of modified mycotoxin zearalenone-14-glucoside (ZEN-14-G) in broilers following oral administration

文献类型： 外文期刊

作者： Okasha Hamada;Haojian Sun;Xue Pan;Decheng Suo;Xia Fan;Zhigang Song

作者机构：

关键词： Broilers;Modified mycotoxins;Toxicokinetic;UHPLC-Q/TOF-MS;Zearalenone-14-glucoside

期刊名称： Poultry Science

ISSN： 0032-5791

年卷期： 2026 年 105 卷 3 期

页码：

收录情况： SCIE（2025版）

摘要： Zearalenone-14-glucoside (ZEN-14-G), a major modified mycotoxin, has attracted considerable attention due to its potential to convert back into free zearalenone (ZEN), thereby posing toxicological risks to animals and humans. Given the limited toxicokinetic data available, this study examined the absorption, distribution, and elimination of ZEN-14-G in Arbor Acres broiler chicks following oral gavage at a dose of 0.5 mg/kg body weight to assess its potential health risks. Blood and tissue samples were collected at 0, 0.5, 1, 6, and 12 h after administration. Plasma concentrations of ZEN-14-G and its primary metabolite, ZEN, were quantified using a validated UHPLC-Q/TOF-MS method. Pharmacokinetic parameters were derived via non-compartmental analysis. The results demonstrated rapid in vivo hydrolysis of ZEN-14-G to ZEN. After oral administration, ZEN-14-G reached peak plasma concentration (Cmax) rapidly. It exhibited a short elimination half-life (T½), a limited apparent volume of distribution (Vd/F), and low total plasma clearance (CL/F). Notably, ZEN was detected in various tissues, with the highest concentrations observed in the liver, glandular stomach, and pectoral muscle. In summary, these findings underscore the important role of biotransformation in ZEN-14-G metabolism and provide key insights for assessing the health risks associated with broiler exposure to glucoside-modified mycotoxins.

分类号：

  • 相关文献

[1]Effect of epigallocatechin gallate on growth performance and antioxidant capacity in heat-stressed broilers. Xue, Bo,Liu, Longzhou,Luo, Jingxian,Tian, Guangming,Yang, Ye,Song, Jiao.

[2]Manganese source affects manganese transport and gene expression of divalent metal transporter 1 in the small intestine of broilers. Bai, Shi-Ping,Lu, Lin,Wang, Rui-Lian,Zhang, Li-Yang,Luo, Xu-Gang,Bai, Shi-Ping,Lu, Lin,Zhang, Li-Yang,Luo, Xu-Gang,Xi, Lin. 2012

[3]Kinetics of phosphorus absorption in ligated small intestinal segments of broilers. Liu, S. B.,Hu, Y. X.,Liao, X. D.,Lu, L.,Li, S. F.,Zhang, L. Y.,Yang, L.,Suo, H. Q.,Luo, X. G.,Liu, S. B.,Tan, H. Z.,Li, S. F..

[4]The effect of supplemental manganese in broiler diets on abdominal fat deposition and meat quality. Lu, L.,Ji, C.,Luo, X. G.,Liu, B.,Yu, S. X.. 2006

[5]Relative bioavailability of tribasic zinc sulfate for broilers fed a conventional corn-soybean meal diet. Lu Lin,Zhang Li-yang,Luo Xu-gang,Ma Xin-yan. 2015

[6]Solexa Sequencing of MicroRNAs on Chromium Metabolism in Broiler Chicks. Pan, Y. Z.,Wu, S. G.,Zhang, H. J.,Yue, H. Y.,Qi, G. H.,Pan, Y. Z.,Dai, H. C.. 2013

[7]Effects of non-phytate phosphorus levels and phytase sources on growth performance, serum biochemical and tibia parameters of broiler chickens. Jiang, Xian R.,Luo, Fa H.,Wu, Shu G.,Zhang, Hai J.,Yue, Hong Y.,Qi, Guang H.,Qu, Ming R.,Bontempo, Valentino. 2013

[8]Influence of Dietary Calcium and Phosphorus Imbalance on Intestinal NaPi-IIb and Calbindin mRNA Expression and Tibia Parameters of Broilers. Li, Jianhui,Yuan, Jianmin,Guo, Yuming,Sun, Qiujuan,Li, Jianhui,Hu, Xiaofei. 2012

[9]Relative Bioavailability of Zinc-Methionine Chelate for Broilers Fed a Conventional Corn-Soybean Meal Diet. Suo, Haiqing,Lu, Lin,Zhang, Liyang,Luo, Xugang,Zhang, Xueyuan,Li, Hua,Lu, Yufei.

[10]Effects of sodium, 1,25-dihydroxyvitamin D-3 and parathyroid hormone fragment on inorganic P absorption and Type IIb sodium-phosphate cotransporter expression in ligated duodenal loops of broilers. Liao, X. D.,Suo, H. Q.,Lu, L.,Hu, Y. X.,Zhang, L. Y.,Luo, X. G..

[11]Dietary non-phytate phosphorus requirement of broilers fed a conventional corn-soybean meal diet from 1 to 21 d of age. Liu, S. B.,Liao, X. D.,Lu, L.,Li, S. F.,Zhang, L. Y.,Jiang, Y.,Luo, X. G.,Liu, S. B.,Li, S. F.,Wang, L..

[12]Kinetics of iron absorption by in situ ligated small intestinal loops of broilers involved in iron transporters. Zhang, L. Y.,Liao, X. D.,Zhang, L. Y.,Lu, L.,Luo, X. G.,Zhang, L. Y..

[13]Proteome changes in the small intestinal mucosa of broilers (Gallus gallus) induced by high concentrations of atmospheric ammonia. Zhang, Jize,Li, Cong,Tang, Xiangfang,Lu, Qingping,Sa, Renna,Zhang, Hongfu. 2015

[14]The chemical characteristics of organic iron sources and their relative bioavailabilities for broilers fed a conventional corn-soybean meal diet. Zhang, L. Y.,Lu, L.,Zhang, L. Y.,Luo, X. G.,Zhang, L. Y..

[15]An optimal dietary non-phytate phosphorus level of broilers fed a conventional corn-soybean meal diet from 4 to 6 weeks of age. Jiang, Y.,Lu, L.,Li, S. F.,Zhang, L. Y.,Liu, S. B.,Luo, X. G.,Li, S. F.,Wang, L.,Liu, S. B..

[16]Determination of Dietary Iron Requirements by Full Expression of Iron-Containing Enzymes in Various Tissues of Broilers. Ma, Xinyan,Liao, Xiudong,Lu, Lin,Zhang, Liyang,Luo, Xugang,Ma, Xinyan,Li, Sufen.

[17]Relative bioavailabilities of organic zinc sources with different chelation strengths for broilers fed diets with low or high phytate content. Huang, Y. L.,Lu, L.,Xie, J. J.,Li, X. L.,Liu, S. B.,Zhang, L. Y.,Luo, X. G.,Huang, Y. L.,Li, S. F.,Xi, L..

[18]Effects of supplemental zinc source and level on antioxidant ability and fat metabolism-related enzymes of broilers. Liu, Z. H.,Lu, L.,Zhang, L. Y.,Luo, X. G.,Liu, Z. H.,Wang, R. L.,Lei, H. L.,Li, S. F..

[19]Cello-oligosaccharide ameliorates heat stress-induced impairment of intestinal microflora, morphology and barrier integrity in broilers. Song, J.,Jiao, L. F.,Xiao, K.,Luan, Z. S.,Hu, C. H.,Zhan, X. A.,Luan, Z. S.,Shi, B..

[20]Effects of sodium gluconate and phytase on performance and bone characteristics in broiler chickers. Guo, Yanli,Shi, Yanghong,Li, Fadi,Zhen, Chen,Hao, Zhengli,Chen, Jilan.

作者其他论文 更多>>