Synergistic modulation of oxidation state of Pt nanozymes via Pd doping and ZIF-67 support enhances the catalytic efficiency for immunoassay detection
文献类型: 外文期刊
作者: Liu, Zhenjiang;Yang, Ying;Yu, Weiguo;Feng, Jiankun;Chen, Hailong;Li, Runan;Li, Longhua;Xue, Yuan
作者机构:
关键词: Nanozymes;Synergistic modulation;Oxidation state;Catalytic efficiency;Immunoassay
期刊名称: BIOSENSORS & BIOELECTRONICS
ISSN: 0956-5663
年卷期: 2025 年 295 卷
页码:
收录情况: SCIE(2025版) ; ; EI(2025版)
摘要: Modulating the oxidation state of active sites presents a promising strategy for enhancing catalytic performance. However, the intrinsic electronic properties of a single regulatory strategy make it difficult to accurately control the oxidation state of nanozymes. Herein, we design high-efficiency PtXPd1@ZIF-67 nanozymes by integrating two modulation strategies (Pd doping and ZIF-67 support) to effectively regulate the oxidation state of the Pt active center. The results demonstrate that Pt4Pd1@ZIF-67 nanozyme with a moderate oxidation state exhibits the best catalytic activity, which is 1.97- and 3.87-fold higher than that of Pt@ZIF-67 and Pt@ZIF-67-S (S represents the removal of ZIF-67 support), respectively. Theoretical calculations indicate that the moderate oxidation state of Pt enhances the adsorption of OH, thereby reducing the energy barrier of the key reaction step (2*OH -> *O + H2O) and ultimately improving the catalytic activity of nanozyme. Crucially, Pt4Pd1@ZIF-67 nanozyme was successfully employed to develop a novel indirect competitive immunoassay for the detection of zearalenone, with a limit of detection of 0.534 ng L-1. This work provides a potential strategy for the rational design of high catalytic performance nanozymes for immunoassay detection.
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