文献类型： 外文期刊
作者： Ren, Hongyan;Zheng, Xinmin;Bi, Yanzhen;Li, Kui;Tao, Cong
作者机构：
关键词： MicroRNA-200s; Gene targeting; Cre-loxp
期刊名称： APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
ISSN： 0273-2289
年卷期： 2017 年 182 卷 3 期
页码：
摘要： MicroRNA-8 and its target gene, u-shaped (ush), regulate body size in Drosophila. As the mouse homolog of the Drosophila miR-8, whether the miR-200 family has similar functions and how they perform their regulatory roles in body size control is unknown. In order to discover the biological function of the miR-200s in vivo, we generated mice lacking the miR-200b/200a/429 gene cluster using the Cre/loxp system. miR-200b/200a/429 null mutant mice were viable, fertile, and showed normal development.
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