1GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos

作者： 左二伟; ; 袁堂龙; JCR（2021版）

机构： Univ Calif San Diego, La Jolla, CA 92093 USA; ;Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA; ;Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai Inst Biol Sci,Shanghai Res Ctr Brain Sci, Inst Neurosci,State Key Lab Neurosci,Key Lab Prim, Shanghai, Peoples R China; ;Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai, Peoples R China; ;Univ Chinese Acad Sci, Chinese Acad Sci Shanghai, Biomed Big Data Ctr,Shanghai Inst Nutr & Hlth,Sha, CAS MPG Partner Inst Computat Biol,Key Lab Comput, Shanghai, Peoples R China; ;Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R C;

来源：Nature Protocols

年份：2020

2Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects

作者： 左二伟; ; 袁堂龙;

来源：Science Advance

年份：2020

3A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects

作者： 左二伟; ; 袁堂龙; ; 刘敬; JCR（2021版）

机构： Univ Chinese Acad Sci, Chinese Acad Sci, Biomed Big Data Ctr,Shanghai Inst Nutr & Hlth,Sha, CAS MPG Partner Inst Computat Biol,Key Lab Comput, Shanghai, Peoples R China; ;Shanghai Acad Sci & Technol, Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China; Chinese Acad Sci, Inst Neurosci,Shanghai Inst Biol Sci, State Key Lab Neurosci,Shanghai Res Ctr Brain Sci, Key Lab Primate Neurobiol,CAS Ctr Excellence Brai, Shanghai, Peoples R China; ;Univ Chinese Acad Sci, Chinese Acad Sci, Biomed Big Data Ctr,Shanghai Inst Nutr & Hlth,Sha, CAS MPG Partner Inst Computat Biol,Key Lab Comput, Shanghai, Peoples R China; ;Chinese Acad Sci, Inst Neurosci,Shanghai Inst Biol Sci, State Key Lab Neurosci,Shanghai Res Ctr Brain Sci, Key Lab Primate Neurobiol,CAS Ctr Excellence Brai, Shanghai, Peoples R China; ;Shanghai Jiao Tong Univ, Shanghai Childrens Hosp,;

来源：Nature Methods

年份：2020