1Discovery of conformation constrained tetracyclic compounds as potent chitinase OfChi-h inhibitors with a novel binding mode

作者： Pengtao Yuan; Xi Jiang; Xintong Ni; Xusheng Shao; Xuhong Qian; Qing Yang; SCIE（2025版）

来源：JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

关键词： Chitinase conformation restriction inhibitor inhibitory mechanism Animals Binding Sites Chitinases Dose-Response Relationship Drug Drug Discovery Enzyme Inhibitors Molecular Conformation Molecular Docking Simulation Molecular Structure Moths Structure-Activity Relationship chitinase inhibitor dipyridopyrimidine 3 carboxamide derivative glycosidase inhibitor hydrogen unclassified drug enzyme inhibitor agricultural pest Article carbon nuclear magnetic resonance catalysis column chromatography conformation crystallization drug protein binding enzyme inhibition hydrogen bond mass spectrometry molecular docking nonhuman nuclear magnetic resonance spectroscopy Ostrinia furnacalis pest control proton nuclear magnetic resonance Serratia marcescens structure activity relation animal binding site chemical structure chemistry dose response drug development drug effect enzymology metabolism moth synthesis

年份：2025