数字农科院2.0

肠炎沙门菌感染鸡lncRNA表达谱分析

文献类型： 中文期刊

作者： 张琪;张锦;王杰;郑炬梅;李庆贺;郑麦青;文杰;赵桂苹

作者机构：

关键词： 鸡; 肠炎沙门菌; lncRNA; 免疫反应

期刊名称：中国家禽

ISSN： 1004-6364

年卷期： 2021 年 43.0 卷 7.0 期

页码：

收录情况： 北大核心（2020版） ; 农林核心（2020版）

摘要： 研究旨在分析鸡感染肠炎沙门菌后长链非编码RNA(lncRNA)的表达谱,了解lncRNA在肠炎沙门菌感染过程中发挥的作用。通过提取脾脏组织总RNA进行高通量测序,利用生物信息学方法进行比较分析。根据差异显著的lncRNAs与mRNAs之间的位置关系预测lncRNAs顺式调控的邻近基因,并对邻近基因进行GO富集和KEGG分析,预测lncRNA的功能。结果显示:在肠炎沙门菌感染过程中共鉴定到2911个lncRNAs,差异表达分析后共筛选到117个差异表达的lncRNAs(DE-lncRNA),随机抽取7个差异表达的lncRNAs进行实时荧光定量验证,在所有差异表达的lncRNAs中有5个(4.27%)在差异表达mRNA附近被转录,lncRNA TCONS_00375517被预测与多个防御素家族基因DE-mRNAs之间可能存在顺式调控作用。结果提示lncRNA可能参与调控鸡抗沙门菌的免疫反应。

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