表皮生长因子受体与肺脏发育的关系
文献类型: 中文期刊
作者: 李海静;刘岩;郝海生;杜卫华;赵学明;王栋;秦彤;马友记;朱化彬
作者机构:
关键词: EGFR;肺泡Ⅱ型上皮细胞;肺脏表面活性物质;肺癌
期刊名称:遗传
ISSN:
年卷期: 2011 年 01 期
页码: 29-34
收录情况: CSCD
摘要: 表皮生长因子受体(Epidermalgrowthfactorreceptor,EGFR)是一种跨膜蛋白受体,是ErbB家族成员之一,具有酪氨酸激酶活性。EGFR与相应的配体结合引起EGFR形成同源或异源二聚体启动胞内信号转导,激活下游多种信号转导途径,产生生物学效应,RAS/RAF/MEK/ERK通路与细胞增殖、分化和凋亡有关;PI3K/PDK1/AKT通路与细胞的迁移和粘附有关。EGFR能促进肺泡II型上皮细胞的成熟和肺表面活性物质的合成、分泌。EGFR对哺乳动物肺脏的作用呈现时空效应及剂量依赖效应,EGFR的下调表达则会引起肺脏发育不成熟;而EGFR过度表达促进肺肿瘤细胞的增殖、侵袭...
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