数字农科院2.0

表皮生长因子受体与肺脏发育的关系

文献类型： 中文期刊

作者： 李海静;刘岩;郝海生;杜卫华;赵学明;王栋;秦彤;马友记;朱化彬

作者机构：

关键词： EGFR;肺泡Ⅱ型上皮细胞;肺脏表面活性物质;肺癌

期刊名称：遗传

ISSN： 0253-9772

年卷期： 2012 年 34 卷 01 期

页码： 29-34

收录情况： 北大核心 ; CSCD

摘要： 表皮生长因子受体(Epidermal growth factor receptor,EGFR)是一种跨膜蛋白受体,是ErbB家族成员之一,具有酪氨酸激酶活性。EGFR与相应的配体结合引起EGFR形成同源或异源二聚体启动胞内信号转导,激活下游多种信号转导途径,产生生物学效应,RAS/RAF/MEK/ERK通路与细胞增殖、分化和凋亡有关;PI3K/PDK1/AKT通路与细胞的迁移和粘附有关。EGFR能促进肺泡II型上皮细胞的成熟和肺表面活性物质的合成、分泌。EGFR对哺乳动物肺脏的作用呈现时空效应及剂量依赖效应,EGFR的下调表达则会引起肺脏发育不成熟;而EGFR过度表达促进肺肿瘤细胞的增殖、侵袭和转移。文章综述了EGFR及其调节信号通路的研究进展,以及EGFR与动物肺脏发育不成熟和肺癌之间的关系。

分类号： R734.2

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