数字农科院2.0

牛支原体黏附素及黏附素结合蛋白研究进展

文献类型： 中文期刊

作者： 武琪;张玉娟;刘桐;辛九庆;徐青元

作者机构：

关键词： Mycoplasma bovis;黏附素;黏附素结合蛋白

期刊名称：畜牧兽医学报

ISSN： 0366-6964

年卷期： 2023 年

页码：

收录情况： 北大核心（2020版） ; ; CSCD（2023-2024年度） ; ; 科技核心（2023版） ; ; 农林核心（2020版）

摘要： 牛支原体（M. bovis）是感染牛的一种重要病原体，可导致感染牛出现肺炎、关节炎、乳房炎、角膜结膜炎和生殖道炎等多种临床症状，给养牛业造成了巨大经济损失。M. bovis黏附素在M. bovis致病过程中发挥重要作用，包括病原感染、细胞入侵、免疫逃逸和毒力产生。到目前为止已鉴定出十多种M. bovis黏附素。这些黏附素主要结合宿主细胞的纤溶酶原（plasminogen， Plg）、纤连蛋白（fibronectin， FN）、硫酸肝素（heparin sulfate， HS）和淀粉样前体样蛋白-2（amyloid precursor-like protein-2， APLP2）。本文将对目前已知的M. bovis黏附素及其宿主细胞靶蛋白的研究现状进行综述，为M. bovis已知和未知黏附素的鉴定和应用提供参考。

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