数字农科院2.0

通用型流感疫苗研究进展

文献类型: 中文期刊

作者: 马继红;于海;童光志

作者机构:

关键词: 通用型流感疫苗;M2e;HA;NP

期刊名称:中国动物传染病学报

ISSN: 1674-6422

年卷期: 2011 年 01 期

页码: 76-82

摘要: 疫苗免疫是目前防控流感病毒感染最有效的策略。现有流感疫苗在不同亚型间的交叉保护力较差,并且由于HA和NA蛋白存在抗原漂移和转换现象,极大地影响了现有疫苗的免疫保护效果,甚至导致疫苗免疫失败。而动物模型研究结果显示,基于流感病毒基因组保守区域的疫苗能够对不同型或亚型的流感病毒产生广谱的交叉保护,本文主要介绍基于M2e、HA和NP的通用型流感型疫苗研究进展。

分类号: R392.1

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