数字农科院2.0

An overview of aflatoxin B1 biotransformation and aflatoxin M1 secretion in lactating dairy cows

文献类型： 外文期刊

作者： Li Min;Johanna Fink-Gremmels;Dagang Li;Xiong Tong;Jing Tang;Xuemei Nan;Zhongtang Yu;Weidong Chen;Gang Wang

作者机构：

关键词： Aflatoxin B1; Aflatoxin M1; Biotransformation; Dairy cow; Milk safety

期刊名称： Anim. Nutr.

ISSN： 2405-6545

年卷期： 2021 年 7 卷 1 期

页码：

收录情况： JCR（2021版）

摘要： Milk is considered a perfect natural food for humans and animals. However, aflatoxin B1 (AFB1) contaminating the feeds fed to lactating dairy cows can introduce aflatoxin M1 (AFM1), the main toxic metabolite of aflatoxins into the milk, consequently posing a risk to human health. As a result of AFM1 monitoring in raw milk worldwide, it is evident that high AFM1 concentrations exist in raw milk in many countries. Thus, the incidence of AFM1 in milk from dairy cows should not be underestimated. To further optimize the intervention strategies, it is necessary to better understand the metabolism of AFB1 and its biotransformation into AFM1 and the specific secretion pathways in lactating dairy cows. The metabolism of AFB1 and its biotransformation into AFM1 in lactating dairy cows are drawn in this review. Furthermore, recent data provide evidence that in the mammary tissue of lactating dairy cows, aflatoxins significantly increase the activity of a protein, ATP-binding cassette super-family G member 2 (ABCG2), an efflux transporter known to facilitate the excretion of various xenobiotics and veterinary drugs into milk. Further research should focus on identifying and understanding the factors that affect the expression of ABCG2 in the mammary gland of cows. © 2021 Chinese Association of Animal Science and Veterinary Medicine

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