数字农科院2.0

Advances in conventional and innovative anti-allergic agents for managing food allergies: from mechanisms to challenges

文献类型： 外文期刊

作者： Zhu, Yuying;Zhou, Enning;Chen, Gang;Kamal-Eldin, Afaf;Wu, Liming;Li, Qiangqiang

作者机构：

关键词： food allergy;anti-allergic agents;natural bioactive ingredients;nano/micro-carriers;nanoparticles

期刊名称： CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

ISSN： 1040-8398

年卷期： 2025 年

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Food allergies constitute a significant and escalating global public health issue. Over the past decade, efforts have intensified to prevent and treat these allergies, including exploring new anti-allergic agents and natural bioactive compounds with minimal side effects. Despite progress, consensus on effective strategies remains elusive. This study undertakes a comprehensive review and discussion of current anti-allergic medications, natural bioactive ingredients, and innovative nano/micro-carriers, focusing on four key mechanisms: binding to allergen epitopes, modulating gut microbiota, restoring intestinal epithelial integrity, and regulating immune responses. Many natural compounds show effectiveness through multiple pathways. Advances in nanotechnology have improved delivery systems such as nanoparticles and sporopollenin exine capsules, enhancing targeted delivery and efficacy. Given the distinct cellular and molecular targets of these anti-allergic agents, investigating synergies between natural and synthetic drugs is essential. For instance, combine traditional anti-allergic drugs with glucocorticoids to quickly relieve initial symptoms; then, use natural agents like probiotics for immune regulation, reducing treatment time and recurrence risk. This review lays the foundation for a scientific framework to guide the future development of combination therapy models in clinical applications.

分类号：

  • 相关文献

[1]Synthesis and Degradation of the Major Allergens in Developing and Germinating Soybean Seed. Wu, Yong-Mei,Guan, Rong-Xia,Liu, Zhang-Xiong,Chang, Ru-Zhen,Qiu, Li-Juan,Wu, Yong-Mei,Li, Run-Zhi. 2012

[2]Desulfurization and bio-regeneration of adsorbents with magnetic P-delafieldii R-8 cells. Li, Wangliang,Xing, Jianmin,Li, Yuguang,Xiong, Xiaochao,Liu, Huizhou,Li, Wangliang,Li, Yuguang,Xiong, Xiaochao,Li, Xin. 2008

[3]Tangeretin-loaded protein nanoparticles fabricated from zein/beta-lactoglobulin: Preparation, characterization, and functional performance. Chen, Jingjing,Zheng, Jinkai,McClements, David Julian,Xiao, Hang,Zheng, Jinkai. 2014

[4]A SIMPLE ROUTE TO CONTROLLABLY SYNTHESIZE WATER-SOLUBLE ZNCDTE NANORODS AND NANOPARTICLES. Wang Yan,Cui Hai-Xin,Sun Chang-Jiao,Hou Yan-Bing,Lu Yun-Zhang. 2011

[5]Enhanced Germicidal Efficacy by Co-Delivery of Validamycin and Hexaconazole with Methoxy Poly(ethylene glycol)-Poly(lactide-co-glycolide) Nanoparticles. Zhang, Jiakun,Zhao, Caiyan,Wu, Yan,Zhang, Jiakun,Liu, Yajing,Cao, Lidong,Huang, Qiliang.

[6]In situ SERS detection of emulsifiers at lipid interfaces using label-free amphiphilic gold nanoparticles. Li, Yue,Driver, Michael,Winuprasith, Thunnalin,Zheng, Jinkai,McClements, David Julian,He, Lili,Li, Yue,Winuprasith, Thunnalin,Zheng, Jinkai.

[7]Utilization of Chitosan-Lactide Copolymer Nanoparticles as Controlled Release Pesticide Carrier for Pyraclostrobin Against Colletotrichum gossypii Southw. Huang, Qi-Liang,Xu, Lei,Cao, Li-Dong,Li, Feng-Min,Wang, Xiang-Jing.

[8]Alleviation of cadmium-induced root growth inhibition in crop seedlings by nanoparticles. Wang, Meng,Chen, Shibao,Ma, Yibing,Chen, Li.

[9]Construction of novel amphiphilic chitosan copolymer nanoparticles for chlorpyrifos delivery. Zhang, Jiakun,Li, Min,Huang, Qiliang,Fan, Tengfei,Xu, Qing,Wu, Yan,Chen, Chunying.

[10]Improving the Effectiveness of (-)-Epigallocatechin Gallate (EGCG) against Rabbit Atherosclerosis by EGCG-Loaded Nanoparticles Prepared from Chitosan and Polyaspartic Acid. Hong, Zhiyong,Jin, Jianchang,Du, Qizhen,Xu, Yongquan,Yin, Jun-Feng,Jiang, Yongwen,Xu, Yongquan,Yin, Jun-Feng,Jiang, Yongwen.

[11]Induction of mucosal immune responses and protection of cattle against direct-contact challenge by intranasal delivery with foot-and-mouth disease virus antigen mediated by nanoparticles. Pan, Li,Zhang, Zhongwang,Lv, Jianliang,Zhou, Peng,Hu, Wenfa,Fang, Yuzhen,Chen, Haotai,Liu, Xinsheng,Shao, Junjun,Zhao, Furong,Ding, Yaozhong,Lin, Tong,Chang, Huiyun,Zhang, Jie,Zhang, Yongguang,Wang, Yonglu,Zhang, Zhongwang,Lv, Jianliang,Zhou, Peng,Hu, Wenfa,Fang, Yuzhen,Chen, Haotai,Liu, Xinsheng,Shao, Junjun,Zhao, Furong,Ding, Yaozhong,Lin, Tong,Chang, Huiyun,Zhang, Jie,Zhang, Yongguang,Wang, Yonglu. 2014

[12]Fast and selective recognizes polysaccharide by surface molecularly imprinted film coated onto aldehyde-modified magnetic nanoparticles. Huang, Weiwei,Yang, Xin,Zhao, Song,Zhang, Min,Hu, Xinglong,Wang, Jing,Zhao, Haitian,Huang, Weiwei,Yang, Xin,Zhang, Min,Wang, Jing,Huang, Weiwei.

[13]Analysis of Small Molecule Compounds by Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry with ZnO, CuO and NiO Nanoparticles as Matrix. Yang Meng-Rui,Wang Min,Tang Xiao-Yan,Zhou Jian,Mao Xue-Fei. 2015

[14]Metabolomics and transcriptomics reveal the toxic mechanism of Cd and nano TiO2 coexposure on rice (Oryza sativa L.). Liwen Qiang,Nan Zhao,Kaizhen Liao,Xichao Sun,Qiang Wang,Hangbiao Jin. 2023

[15]Enhanced Plant Growth Promoting Role O.f Mpeg-Plga-Based Nanoparticles As A n Activator Protein Peat1 Carrier In Wheat (Triticum Aestivum L.). Guo, Rong,Qiu, Dewen,Gao, Han,Fu, Yuming,Qin, Youcai,Fu, Yuming,Qin, Youcai,Guo, Rong,Gao, Han,Wu, Yan,Fu, Yuming. 2018

[16]The Use Of Human Umbilical V.ein Endothelial Cells (Huvecs) A s An In Vitro Model To Assess The Toxicity Of Nanoparticles To Endothelium: A Review. Cao, Y, Gong, Y, Liu, LL, Zhou, YW, Fang, X, Zhang, C, Li, YN, Li, J. 2017

[17]Characterization And Toxicity Of Nanoscale F.ragments In Wastewater Treatment P lant Effluent. Hu, XG, Ren, CX, Kang, WL, Mu, L, Liu, XW, Li, XK, Wang, T, Zhou, QX. 2018

[18]Preparation And Characterisation Of Ginkgolide N.anoparticles Via The Emulsion S olvent Evaporation Method. Jiang, JF, Ao, J, He, CY, Xiong, J, Zhao, JQ, Liu, JT, You, SR, Jiang, H. 2018

[19]Green Synthesis of Zinc Oxide (ZnO) Nanoparticles from Green Algae and Their Assessment in Various Biological Applications. Hajra Hameed,Abdul Waheed,Muhammad Shakeeb Sharif,Muhammad Saleem,Afshan Afreen,Muhammad Tariq,Asif Kamal,Wedad A. Al-onazi,Dunia A. Al Farraj,Shabir Ahmad,Rania M. Mahmoud. 2023

[20]Design of PLGA nanoparticles for sustained release of hydroxyl-FK866 by microfluidics. Bai, Xue,Tang, Siyuan,Butterworth, Sam,Tirella, Annalisa. 2023

作者其他论文 更多>>