数字农科院2.0

Multi-Omics Integration Reveals Key Genes, Metabolites and Pathways Underlying Meat Quality and Intramuscular Fat Deposition Differences Between Tibetan Pigs and Duroc × Tibetan Crossbred Pigs

文献类型： 外文期刊

作者： Junda Wu;Qiuyan Huang;Baohong Li;Zixiao Qu;Xinming Li;Fei Li;Haiyun Xin;Jie Wu;Chuanhuo Hu;Sen Lin;Xiangxing Zhu;Dongsheng Tang;Chuang Meng;Zongliang Du;Erwei Zuo;Fanming Meng;Sutian Wang

作者机构：

关键词： IMF deposition;local pig breeds;multi-omics;pork quality

期刊名称： Animals

ISSN：

年卷期： 2026 年 16 卷 2 期

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收录情况： SCIE（2025版）

摘要： The sensory quality of pork constitutes a complex phenotype that arises from the interplay between genetic factors and environmental conditions. As a local pig breed in China, Tibetan pigs (TPs) are known for their high-quality meat. However, their slow growth rate and low production efficiency limit their large-scale breeding. We have used Duroc as a hybrid sire to improve TP. Our study found that TPs have higher intramuscular fat content and higher levels of monounsaturated fatty acids. Duroc × Tibetan crossbred pigs (DZs) not only retain the paternal high productivity but also inherit the superior meat quality of the maternal parent. Transcriptome analysis identified IL6, GPX1, GPX3, AOX1, ALDH7A1, PTGS2, NFKBIA, ADIPOQ and PPARG as being involved in affecting meat quality. Metabolomic analysis found that betaine, carnosine, L-carnitine, and lysophosphatidylcholine were important components that affect meat quality. Joint analysis further reveals that the expression of ATF4, DGKB, GNMT, and ADSL genes is closely related to arachidonic acid, lysophosphatidylcholine, betaines, and hypoxanthine, ultimately affecting the quality of the meat. By comprehensively analyzing the carcass and meat quality traits, genes and metabolites affecting meat quality traits, this study provides new evidence for improving pork quality and guiding breeding strategies.

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