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Aminopeptidase M17 in bacteria: insights into structure, function, and potential as a drug target

文献类型： 外文期刊

作者： Askar, Hussam;Chen, Shengli;Hao, Huafang;Jin, Xiangrui;Adel Baz, Ahmed;Lan, Shimei;Li, Zhangcheng;Chu, Yuefeng

作者机构：

关键词： leucyl-aminopeptidase;M17;biological functions;drug target;antibiotic resistance

期刊名称： JOURNAL OF BACTERIOLOGY

ISSN： 0021-9193

年卷期： 2025 年

页码：

收录情况： SCIE（2025版）

摘要： Leucyl-aminopeptidase (LAP) is a type of protease that targets peptides and the nitrogen terminus of protein molecules, playing a key role in the removal of amino acids. This function is not only significant but also enlightening, as it contributes to our understanding of microbial survival and persistence. The presence of M17-LAPs enzymes across various bacterial species indicates the possibility of creating selective inhibitors, offering new avenues for antimicrobial development amidst increasing antibiotic resistance. Additionally, understanding the relationship between the structure of these enzymes and their functions can aid in the development of more effective treatment methods and enhance current therapies. In this review, we unravel the structural blueprints, functional roles, and therapeutic promise of M17-LAPs, highlighting their relevance in the era of escalating antibiotic resistance. We also highlight future research avenues, emphasizing structural biology and protein-protein interaction mapping as keys to unlocking targeted therapeutic strategies. By bridging molecular structure with translational potential, we propose a new vision: harnessing the vulnerabilities of M17-LAPs to inspire next-generation antibacterial strategies.

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