数字农科院2.0

Aggregation-Induced Emission Ionic Liquids for Bacterial Imaging, Biofilm Inhibition, and Mixed Bacterial Infection Wound Healing

文献类型： 外文期刊

作者： Gao, Chenxi;Fu, Lei;Wang, Juanjuan;Chu, Yuefeng;Gao, Luyao;Qiu, Hongdeng;Chen, Jia

作者机构：

关键词： Ionic liquids;Aggregation-induced emission;Bacterial imaging;Biofilm inhibition;Woundhealing

期刊名称： CHEMICAL & BIOMEDICAL IMAGING

ISSN： 2832-3637

年卷期： 2025 年

页码：

收录情况： CSCD（2025-2026年度） ; ; ESCI（2025版）

摘要： The excessive utilization of antibiotics escalates the susceptibility to bacterial infections in the general populace. The misuse of antibiotics and the emergence of bacterial resistance can be effectively regulated through the implementation of bacterial detection technology. Therefore, the construction of a multifunctional platform for bacterial detection and removal holds immense significance. In this research, we have effectively developed an imidazolium ionic liquid (TPE-IL) based on the tetraphenylethylene (TPE) structure with aggregation-induced emission (AIE), enabling effective bacterial imaging, biofilm inhibition, and mixed bacterial infection wound healing. TPE-IL effectively targets and penetrates bacterial surfaces via the electrostatic interactions of its imidazole groups and the hydrophobic interactions of its alkyl chains. This dual-action mechanism not only enhances fluorescence emission from the bacterial surface, enabling precise bacterial imaging, but also exhibits significant bactericidal activity. TPE-IL revealed superior antibacterial activity against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The in vitro anti-biofilm experiments demonstrated that TPE-IL exhibited remarkable inhibitory effects on biofilms formed by S. aureus and E. coli. The in vivo antibacterial experiments confirmed the potent in vivo bactericidal activity of TPE-IL, which significantly reduced inflammatory responses, enhanced collagen deposition, and promoted wound healing without inducing organ damage in mice. Moreover, TPE-IL displayed low cytotoxicity and hemolysis rate. This work has successfully developed a safe and effective platform for bacterial identification and antimicrobial treatment, thereby offering significant implications in addressing the challenges associated with antibiotic resistance and misuse.

分类号：

  • 相关文献

[1]Antibacterial Activity and Action Mechanism of the Echinops ritro L. Essential Oil Against Foodborne Pathogenic Bacteria. Jiang, Bin,Wang, Fei,Liu, Lei,Tian, Shangyi,Li, Wenliang,Huang, Yanxin,Yi, Jingwen,Li, Yuxin,Li, Wenliang,Wu, Yin,Yu, Chunlei,Sun, Luguo,Yang, Xiaoguang,Zhang, Yuwei.

[2]New Insights into the Antibacterial Activity of Hydroxycoumarins against Ralstonia solanacearum. Yang, Liang,Ding, Wei,Wu, Dousheng,Li, Shili,Chen, Juanni,Guo, Bing,Xu, Yuquan.

[3]Editorial: Exploring zoonoses: therapeutic strategies and drug mechanisms. Lei Tan,Mingxiao Ma,Zhanbo Zhu,Shen Yang. 2025

[4]A novel fluorometric turn-on assay for lipase activity based on an aggregation-induced emission (AIE) luminogen. Shi, Jie,Zhang, Shan,Zheng, Mingming,Deng, Qianchun,Zheng, Chang,Huang, Fenghong,Li, Jing.

[5]A Novel Fluorometric Turn-On Assay F.or Lipase Activity Based O n An Aggregation-Induced Emission (Aie) Luminogen. Shi, J, Zhang, S, Zheng, MM, Deng, QC, Zheng, C, Li, J, Huang, FH. 2017

[6]An Aggregation-Induced Emission Probe Based O.n Host-Guest Inclusion Composed O f The Tetraphenylethylene Motif And Gamma-Cyclodextrin For The Detection Of Alpha-Amylase. Shi, J, Deng, QC, Li, Y, Chai, ZF, Wan, CY, Shangguan, HJ, Li, L, Tang, B. 2019

[7]Aggregation-induced emission-enhanced point-of-care testing method for food safety and environmental monitoring. Liyuan Wang,Xiaofeng Hu,Shenling Wang,Wenqin Wu,Kaiming Wu,Li Yu,Peiwu Li,Zhaowei Zhang. 2025

[8]Ionic-liquid-based, manual-shaking- and ultrasound-assisted, surfactant-enhanced emulsification microextraction for the determination of three fungicide residues in juice samples. Chen, Xiaochu,You, Xiangwei,Liu, Fengmao,Hou, Fan,Zhang, Xu,You, Xiangwei.

[9]Extraction, Preconcentration and Isolation of Flavonoids from Apocynum venetum L. Leaves Using Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with an Aqueous Biphasic System. Tan, Zhijian,Yi, Yongjian,Wang, Hongying,Zhou, Wanlai,Wang, Chaoyun.

[10]Progress of Lipase-Catalyzed Ester Synthesis in Ionic Liquid. Li Jing,Wang Jun,Zhang Leixia,Gu Shuangshuang,Wu Fuan,Guo Yuewei,Wu Fuan,Guo Yuewei. 2012

[11]Ultrasonic Assisted Extraction of Paclitaxel from Taxus x media Using Ionic Liquids as Adjuvants: Optimization of the Process by Response Surface Methodology. Tan, Zhijian,Wang, Chaoyun,Zhou, Wanlai,Yang, Yuanru,Wang, Hongying,Yi, Yongjian,Tan, Zhijian,Wang, Chaoyun,Zhou, Wanlai,Yang, Yuanru,Wang, Hongying,Yi, Yongjian,Li, Qiao,Li, Fenfang.

[12]Assessment Of The Cytotoxicity Of I.onic Liquids On Spodoptera F rugiperda 9 (Sf-9) Cell Lines Via In Vitro Assays. Wu, SG, Zeng, LB, Wang, CY, Yang, YR, Zhou, WL, Li, FF, Tan, ZJ. 2018

[13]Simultaneous Determination of 21 Sulfonamides in Poultry Eggs Using Ionic Liquid-Modified Molecularly Imprinted Polymer SPE and UPLC-MS/MS. Suo, Decheng,Zhang, Su,Song, Zhanteng,Wang, Shi,Li, Yang,Fan, Xia. 2022

作者其他论文 更多>>