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Synergistic impacts of flupyradifurone and uniconazole on oxidative stress biomarkers and immune-related gene expression in honey bees

文献类型： 外文期刊

作者： Chen, Liping;Liu, Qian;Xu, Mingfei;Mao, Liangang;Liu, Xinju;Wang, Dou;Wu, Changxin;Wang, Yanhua

作者机构：

关键词： Toxic mechanism;Synergistic impact;Biomarkers;Pollination insects

期刊名称： ENVIRONMENTAL SCIENCES EUROPE

ISSN： 2190-4707

年卷期： 2025 年 38 卷 1 期

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： BackgroundThe widespread application of pesticides in modern agriculture has been recognized as a key driver of declines in honey bee populations. Butenolide insecticide flupyradifurone (FLU) and triazole-based plant growth regulator uniconazole (UNI) are frequently found together in agricultural ecosystems, raising serious concerns about their combined toxicological impacts on pollinators.ResultsFLU and UNL mixture elicited an acute synergistic toxic effect on A. mellifera, significantly enhancing physiological stress. Enzymatic activity assays revealed notable alterations in the levels of superoxide dismutase (SOD), catalase (CAT), polyphenol oxidase (PPO), and glutathione S-transferase (GST), indicative of intensified oxidative stress, impaired detoxification mechanisms, and compromised immune function. Furthermore, transcriptomic analyses showed that the expression of five key genes, abaecin, domeless, relish, vitellogenin (vtg), and CRBXase, was more profoundly affected under combined exposure compared to individual treatments, highlighting disruptions in immune regulation, longevity pathways, and detoxification processes at the molecular level.ConclusionThese results provided compelling evidence that the co-occurrence of FLU and UNI posed a heightened biochemical and genetic threat to honey bees, likely due to synergistic interactions that amplified their individual toxicities. This study offered crucial insights into the ecological hazards of pesticide combinations. Such informed approaches are vital for minimizing pollinator risk and safeguarding ecosystem services essential to sustainable agriculture.

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