数字农科院2.0

Emission enhancement of core-shell-shell lanthanide nanoparticles functionalized with Pt(IV) prodrugs for deep-tissue signal penetration and chemotherapy

文献类型： 外文期刊

作者： Guofeng Liu;Zhenxing Wang;Wan Sun;Wei Gao;Xiangtong Zhang;Hui Lin;Meng Tian;Lijun Ma;Zhen Li;Rui Wang;Ying Li;Chao Lv;Shicai Xu;Zhijian Tan

作者机构：

关键词： Chemotherapy;Core-shell structure;NIR luminescence;Upconversion

期刊名称： Optical Materials

ISSN： 0925-3467

年卷期： 2025 年 168 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Upconversion nanoparticles (UCNPs) are highly promising candidates for use in medical treatment and biomarker detection. However, a persistent challenge for the broad application of UCNPs in deep-tissue penetration is their characteristically low near-infrared (NIR) quantum yield. In this study, the sandwich-structure nanoparticles (NaYF4: Yb3+/Er3+@NaYF4: Yb3+/Tm3+@NaYF4, hereafter abbreviated as Er@Tm@Y) exhibited an enhanced and broadened emission spectrum (400–850 nm) compared with the core (NaYF4: Yb3+/Er3+) and core@shell (NaYF4: Yb3+/Er3+@NaYF4: Yb3+/Tm3+) structures. The Tm3+ was introduced as the inner shell, which exhibited stronger luminescence emission at 801 nm than that of a traditional core-shell structure (NaYF4: Yb3+/Tm3+@NaYF4). In vitro studies using the nanoparticles' visible green fluorescence confirmed their successful uptake by cancer cells. Furthermore, a tissue phantom study demonstrated that the nanoparticles' NIR-I signal could effectively penetrate through 6 mm of chicken breast tissue, highlighting their great potential for future in vivo deep-tissue imaging. Moreover, we developed multifunctional nanocomposites based on platinum-conjugated lanthanide-doped core-shell-shell nanoparticles (Er@Tm@Y–Pt), which is composed of cis, cis, trans-diamminedichlorodisuccinato-platinum(IV) (DSP) and Er@Tm@Y, has notable inhibitory effects on CT26 cells and tumor, while DSP alone induces less killing effect. This study lays a foundation for the design of nano diagnostic and therapeutic agents.

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