数字农科院2.0

Gut-Testis Axis: Microbiota Prime Metabolome To Increase Sperm Quality in Young Type 2 Diabetes

文献类型： 外文期刊

作者： Yan, Xiaowei;Feng, Yanni;Hao, Yanan;Zhong, Ruqing;Jiang, Yue;Tang, Xiangfang;Lu, Dongxin;Fang, Hanhan;Agarwal, Manjree;Chen, Liang;Zhao, Yong;Zhang, Hongfu

作者机构：

关键词： type 2 diabetes in youth;sperm concentration;sperm motility;spermatogenesis;gut microbiota;DHA;EPA

期刊名称： MICROBIOLOGY SPECTRUM

ISSN： 2165-0497

年卷期： 2022 年

页码：

收录情况： SCIE（2022版）

摘要： A10-FMT benefits gut microbiota, liver function, and systemic environment via improvement in blood metabolome, consequently to favor the testicular microenvironment to improve spermatogenesis process and to boost T2D-diminished semen quality. We established that AOS-improved gut microbiota may be used to boost T2D-decreased semen quality and metabolic disease-related male subfertility. Young type 2 diabetes (T2D) affects 15% of the population, with a noted increase in cases, and T2D-related male infertility has become a serious issue in recent years. The current study aimed to explore the improvements of alginate oligosaccharide (AOS)-modified gut microbiota on semen quality in T2D. The T2D was established in young mice of 5 weeks of age with a blood glucose level of 21.2 +/- 2.2 mmol/L, while blood glucose was 8.7 +/- 1.1 mM in control animals. We discovered that fecal microbiota transplantation (FMT) of AOS-improved microbiota (A10-FMT) significantly decreased blood glucose, while FMT of gut microbiota from control animals (Con-FMT) did not. Sperm concentration and motility were decreased in T2D to 10% to 20% of those in the control group, while A10-FMT brought about a recovery of around 5- to 10-fold. A10-FMT significantly increased small intestinal Allobaculum, while it elevated small intestinal and cecal Lactobacillus in some extent, blood butyric acid and derivatives and eicosapentaenoic acid (EPA), and testicular docosahexaenoic acid (DHA), EPA, and testosterone and its derivatives. Furthermore, A10-FMT improved liver functions and systemic antioxidant environments. Most importantly, A10-FMT promoted spermatogenesis through the improvement in the expression of proteins important for spermatogenesis to increase sperm concentration and motility. The underlying mechanisms may be that A10-FMT increased gut-beneficial microbes Lactobacillus and Allobaculum to elevate blood and/or testicular butyric acid, DHA, EPA, and testosterone to promote spermatogenesis and thus to ameliorate sperm concentration and motility. AOS-improved gut microbes could emerge as attractive candidates to treat T2D-diminished semen quality. IMPORTANCE A10-FMT benefits gut microbiota, liver function, and systemic environment via improvement in blood metabolome, consequently to favor the testicular microenvironment to improve spermatogenesis process and to boost T2D-diminished semen quality. We established that AOS-improved gut microbiota may be used to boost T2D-decreased semen quality and metabolic disease-related male subfertility.

分类号：

  • 相关文献

[1]Alginate oligosaccharides increase boar semen quality by affecting gut microbiota and metabolites in blood and sperm. Han, Hui,Zhou, Yexun,Xiong, Bohui,Zhong, Ruqing,Jiang, Yue,Sun, Haiqing,Tan, Jiajian,Zhang, Bin,Guan, Chang,Schroyen, Martine,Chen, Liang,Zhao, Yong,Zhang, Hongfu. 2022

[2]转sFat-1基因猪肉对小鼠血常规血生化及免疫指标的影响. 宋鹏坤,张坚,王春荣,李丽祥,满青青,汤茂学,崔文涛. 2013

[3]长链多不饱和脂肪酸的替代来源——转基因油料作物. 胡亚平,吴刚,张丽,卢长明. 2009

[4]基于核磁共振定量氢谱技术的乳品脂质分析及方法建立. 李强强,朱丹,逄秀梅,王雪,刘悦,陈刚,孟祥河. 2016

[5]长链多不饱和脂肪酸EPA、DHA的基因工程研究进展. 李文宗,王磊. 2016

[6]利用近红外光谱技术快速测定鱼油中EPA和DHA含量的方法研究. 王楠,于宏威,李军国,秦玉昌. 2017

[7]不同加热条件对ω-3鸡蛋中脂肪酸含量的影响. 王瑶瑶,吴凡,叶根军,梁克红,赵雪梅,伊素芹,王晓红,朱大洲. 2021

[8]Gut microbiota-testis axis: FMT improves systemic and testicular micro-environment to increase semen quality in type 1 diabetes. Yanan Hao,Yanni Feng,Xiaowei Yan,Liang Chen,Ruqing Zhong,Xiangfang Tang,Wei Shen,Qingyuan Sun,Zhongyi Sun,Yonglin Ren,Hongfu Zhang,Yong Zhao. 2022

[9]Skin hyperspectral imaging and machine learning to accurately predict the muscular poly-unsaturated fatty acids contents in fish. Yi Ming Cao,Yan Zhang,Qi Wang,Ran Zhao,Mingxi Hou,Shuang Ting Yu,Kai Kuo Wang,Ying Jie Chen,Xiao Qing Sun,Shijing Liu,Jiong Tang Li. 2024

[10]DHA Suppresses Hepatic Lipid Accumulation via Cyclin D1 in Zebrafish. Qianwen Ding,Qiang Hao,Qingshuang Zhang,Yalin Yang,Rolf Erik Olsen,Einar Ringø,Chao Ran,Zhen Zhang,Zhigang Zhou. 2022

[11]Excess DHA Induces Liver Injury via Lipid Peroxidation and Gut Microbiota-Derived Lipopolysaccharide in Zebrafish. Ding, Qianwen,Hao, Qiang,Zhang, Qingshuang,Yang, Yalin,Olsen, Rolf Erik,Ringo, Einar,Ran, Chao,Zhang, Zhen,Zhou, Zhigang. 2022

[12]Gut microbiota dysbiosis and oxidative damage in high-fat diet-induced impairment of spermatogenesis: Role of protocatechuic acid intervention. Hu, Ruizhi,Yang, Xizi,Wang, Long,Su, Dingding,He, Ziyu,Li, Jiaxing,Gong, Jiatai,Zhang, Wentao,Ma, Siqi,Shi, Mingkun,Lv, Jing,Zhang, Qianjin,Hou, De-Xing,Zhang, Hongfu,He, Jianhua,Yin, Yulong,Wang, Jun,Wu, Shusong. 2024

[13]The structuring mechanism and in vitro digestion of novel EPA-rich medium- and long-chain triacylglycerol oleogels. Suyuan Zhao,Yan Zhu,Liwen Zhang,Fang Hu,Wei Xu,Mingming Zheng,Yibin Zhou,Shiyi Li. 2025

[14]Changes in seminal plasma microecological dynamics and the mechanistic impact of core metabolite hexadecanamide in asthenozoospermia patients. Han, Baoquan,Wang, Yongyong,Ge, Wei,Wang, Junjie,Yu, Shuai,Yan, Jiamao,Hua, Lei,Zhang, Xiaoyuan,Yan, Zihui,Wang, Lu,Zhao, Jinxin,Huang, Cong,Yang, Bo,Wang, Yan,Ma, Qian,Zhao, Yong,Jiang, Hui,Zhang, Yunqi,Liang, Shaolin,Zhao, Jianjuan,Sun, Zhongyi,Shen, Wei,Gui, Yaoting. 2024

[15]The In Vitro Evaluation of Rooster Semen Pellets Frozen with Dimethylacetamide. Shaimaa K. Hamad,Ahmed M. Elomda,Yanyan Sun,Yunlei Li,Yunhe Zong,Jilan Chen,Ahmed O. Abbas,Farid K.R. Stino,Ali Nazmi,Gamal M.K. Mehaisen. 2023

[16]Research note: Chicken seminal plasma metabolome and fertility-enhancing effects of L-carnitine supplementation in semen. Yunlei Li,Lijun Jiang,Yunhe Zong,Aixin Ni,Xintong Han,Adamu Mani Isa,Jingwei Yuan,Jilan Chen,Yanyan Sun. 2025

[17]饲粮中添加微藻和亚麻籽提高鸡蛋黄中ω-3多不饱和脂肪酸含量对比研究. 吴永保,杨凌云,闫海洁,蔡辉益,武书庚,于会民,岳洪源,郑尚宁. 2015

[18]温度和碳源对隐甲藻生长及DHA积累的影响. 郭小婧,龚阳敏,梁焯,万霞,胡传炯,刘姣,江木兰. 2013

[19]富含n-3多不饱和脂肪酸功能性原料在家禽生产中的应用研究进展. 吴永保,闫海洁,蔡辉益,张姝. 2015

[20]以藻油为基质的DHA-纳米结构脂质载体的制备和表征. 王佳丽,董绪燕,魏芳,江木兰,黄凤洪,陈洪. 2012

作者其他论文 更多>>