数字农科院2.0

Synthesis and antibacterial activity of FST and its effects on inflammatory response and intestinal barrier function in mice infected with Escherichia coli O78

文献类型： 外文期刊

作者： Ge W.;Li Z.;Yang Y.;Liu X.;Zhu Z.;Bai L.;Qin Z.;Xu X.;Li J.;Li S.

作者机构：

关键词： Antibacterial;FST;Intestinal inflammation;Jejunum injury;Synthesize

期刊名称： International Immunopharmacology

ISSN： 1567-5769

年卷期： 2024 年 127 卷

页码：

收录情况： SCIE（2024版）

摘要： Pathogenic Escherichia coli (E. coli) can cause intestinal diseases in humans and livestock, damage the intestinal barrier, increase systemic inflammation, and seriously threaten human health and the development of animal husbandry. In this study, we designed and synthesized a novel conjugate florfenicol sulfathiazole (FST) based on drug combination principles, and investigated its antibacterial activity in vitro and its protective effect on inflammatory response and intestinal barrier function in E. coli O78-infected mice in vivo. The results showed that FST had superior antibacterial properties and minimal cytotoxicity compared with its prodrugs as florfenicol and sulfathiazole. FST protected mice from lethal E. coli infection, reduced clinical signs of inflammation, reduced weight loss, alleviated intestinal structural damage. FST decreased the expression of inflammatory cytokines IL-1β, IL-6, TNF-α, and increased the expression of claudin-1, Occludin, and ZO-1 in the jejunum, improved the intestinal barrier function, and promoted the absorption of nutrients. FST also inhibited the expression of TLR4, MyD88, p-p65, and p-p38 in the jejunum. The study may lay the foundation for the development of FST as new drugs for intestinal inflammation and injury in enteric pathogen infection. © 2023 Elsevier B.V.

分类号：

  • 相关文献

[1]DissectingthemaizedirectandindirectdefenseresponseagainstAsianCornBorer. 汪海,李圣彦,查象敏,朱莉,黄大昉,郎志宏. 2015

[2]德保矮马X染色体选择信号筛选. 刘雪雪,阿地力江·卡德尔,董坤哲,王月月,潘建飞,浦亚斌,何晓红,马月辉,蒋琳. 2015

[3]全基因组选择信号揭示绒山羊绒毛性状相关的候选基因. 金美林,陆健,费晓娟,卢曾奎,权凯,储明星,狄冉,王慧华,魏彩虹. 2020

[4]全基因组选择信号揭示绵羊毛囊发育及脱毛性状相关的候选基因. 雷志惠,张利平,赵洪昌,朱韶华,卢曾奎,郭婷婷,孙渭博,赫雪,岳耀敬. 2022

[5]Genetic parameters estimation and genome molecular marker identification for gestation length in pigs. Lijun Shi,Huihui Li,Lixian Wang. 2023

[6]Whole genome re-sequencing reveals artificial and natural selection for milk traits in East Friesian sheep. Li X.,Yuan L.,Wang W.,Zhang D.,Zhao Y.,Chen J.,Xu D.,Zhao L.,Li F.,Zhang X.. 2022

[7]Genome-wide selection signal analysis reveals the adaptability of Tibetan sheep to high altitudes. Song, Yufang,Yuan, Chao,Guo, Tingting,Chen, Bowen,Wang, Fan,Lu, Zengkui,Liu, Jianbin. 2025

[8]Dietary organic acids ameliorate high stocking density stress-induced intestinal inflammation through the restoration of intestinal microbiota in broilers. Dong Dai,Guanghai Qi,Jing Wang,Haijun Zhang,Kai Qiu,Yanming Han,Yuanyuan Wu,Shugeng Wu. 2022

[9]Dietary Bacillus licheniformis shapes the foregut microbiota, improving nutrient digestibility and intestinal health in broiler chickens. Yunsheng Han,Xin Xu,Jiaxin Wang,Hongying Cai,Daojie Li,Hongwei Zhang,Peilong Yang,Kun Meng. 2023

[10]Metagenomic insights into the composition and function of the gut microbiota of mice infected with Toxoplasma gondii. Jin Xin Meng,Xin Yu Wei,Huanping Guo,Yu Chen,Wei Wang,Hong Li Geng,Xing Yang,Jiang Jiang,Xiao Xuan Zhang. 2023

[11]Algal oil alleviates antibiotic-induced intestinal inflammation by regulating gut microbiota and repairing intestinal barrier. Zhang H.,Xu Z.,Chen W.,Huang F.,Chen S.,Wang X.,Yang C.. 2023

[12]Editorial: Functional feed additives and intestinal health in aquatic animals. Gang Yang,Zhen Zhang,Vikash Kumar. 2024

[13]Effect of dietary aspirin eugenol ester on the growth performance, antioxidant capacity, intestinal inflammation, and cecal microbiota of broilers under high stocking density. Haojie Zhang,Yi Zhang,Dongying Bai,Jiale Zhong,Xiaodi Hu,Ruilin Zhang,Wenrui Zhen,Koichi Ito,Bingkun Zhang,Yajun Yang,Jianyong Li,Yanbo Ma. 2024

[14]Strain specificity of lactobacilli with promoted colonization by galactooligosaccharides administration in protecting intestinal barriers during Salmonella infection. Wu, Yujun,Zhang, Xiangyu,Liu, Xiaoyi,Li, Yi,Han, Dandan,Pi, Yu,Whitmore, Melanie A.,Lu, Xingmiao,Zhang, Guolong,Zheng, Jinkai,Wang, Junjun. 2024

[15]Gut Microbiota Alleviates Intestinal Injury Induced by Extended Exposure to Light via Inhibiting the Activation of NLRP3 Inflammasome in Broiler Chickens. Dandan Ma,Minhong Zhang,Jinghai Feng. 2024

[16]Rosemary (Rosmarinus officinalis L.) polyphenols and inflammatory bowel diseases: Major phytochemicals, functional properties, and health effects. Lianhua Zhang,Jie Lu. 2024

[17]Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus. Zhang, Shunfen,Zhong, Ruqing,Zhou, Miao,Li, Kai,Lv, Huiyuan,Wang, Huixin,Xu, Ye,Liu, Dadan,Ma, Qiugang,Chen, Liang,Zhang, Hongfu. 2025

[18]A Novel Synbiotic Protects Against DSS-Induced Colitis in Mice via Anti-inflammatory and Microbiota-Balancing Properties. Yang, Yong,Qiao, Yuyu,Liu, Ge,Chen, Weihao,Zhang, Ting,Liu, Jing,Fan, Weiping,Tong, Mingwei. 2024

[19]Baicalin alleviates intestinal inflammation and microbial disturbances by regulating Th17/Treg balance and enhancing Lactobacillus colonization in piglets. Shunfen Zhang,Chengzeng Luo,Kai Li,Junhong Wang,Huixin Wang,Ruqing Zhong,Liang Chen,Qiugang Ma,Hongfu Zhang. 2024

[20]Protective effect of a newly probiotic Lactobacillus reuteri LY2-2 on DSS-induced colitis. Yang, Yong,Qiao, Yuyu,Liu, Ge,Yi, Gaoqin,Liu, Hongli,Zhang, Ting,Tong, Mingwei. 2025

作者其他论文 更多>>