数字农科院2.0

Single-cell RNA sequencing reveals T and B cell-related immune features in foot and mouth disease virus-infected mice

文献类型： 外文期刊

作者： Yang Wang;Lihong Zhang;Zhao Zhang;Zhihua Chen;Jingru Xu;Han Zhang;Haixue Zheng;Jingjing Pei

作者机构：

关键词： adaptive immunity;FMDV;scRNA-seq;T and B lymphocytes

期刊名称： Virulence

ISSN： 2150-5608

年卷期： 2025 年 16 卷 1 期

页码：

收录情况： SCIE（2025版）

摘要： T and B lymphocytes protect against the foot and mouth disease virus (FMDV). They are essential for long-term immunity and viral clearance, but their immunological features in FMDV infection remain unknown. Here, we performed single-cell RNA sequencing (scRNA-seq) and conducted integrative analyses to determine cell composition, gene expression, cell-cell communication state, and regulatory network of T and B cells in the spleen of FMDV- and mock-infected mice. Our results revealed variational compositions of immune cells on the subsets level. Additionally, we determined the reshaping of several essential pathways in T and B cells, such as the inhibition of antigen-presentation capacity. Finally, the virus-induced shaping of immune patterns, including cell-cell communication and regulatory networks, was also characterized during FMDV infection. Overall, our research provides valuable insights and resources for understanding the adaptive immune response in FMD.

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