数字农科院2.0

Future of PARP inhibitors in cancer treatment: overcoming resistance and enhancing efficacy with combination therapies

文献类型： 外文期刊

作者： Shoaib, Muhammad;Bhutta, Zeeshan Ahmad;Javed, Ahsan;Amjad, Muhammad Nabeel;Li, Wenzhu;Choi, Kyung-Chul;Pu, Wanxia

作者机构：

关键词： Poly(ADP-ribose) polymerase (PARP);PARP inhibitors (PARPi);Cancer;PARPi resistance;PARPi modulation;Cancer alternative therapy;(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic) (PARP);PARP(sic)(sic)(sic) (PARPi);(sic)(sic);PARPi (sic)(sic)(sic);PARPi (sic)(sic);(sic)(sic)(sic)(sic)(sic)(sic)

期刊名称： JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B

ISSN： 1673-1581

年卷期： 2025 年

页码：

收录情况： SCIE（2025版） ; ; CSCD（2025-2026年度） ; ; 科技核心（2024版）

摘要： Poly(ADP-ribose) polymerase (PARP) is a family of proteins that play a crucial role in diverse cellular processes, including DNA repair, cell death, and changes in chromatin structure. PARP inhibitors (PARPi) have been recognized as notable agents in the realm of anticancer therapeutics owing to their capacity to specifically impact DNA repair pathways, thereby inducing targeted death of cancerous cells, particularly in cancers with homologous recombination deficiency (HRD). These inhibitors have been approved for the treatment of several cancers, such as ovarian, breast, and pancreatic cancers. Despite their promising therapeutic attributes, developing resistance to PARPi presents a formidable obstacle, curtailing their overall efficacy. This article presents a comprehensive description of the potential mechanisms related to PARPi resistance, an in-depth study of potential strategies to overcome resistance, and an assessment of the therapeutic potential of the PARPi in combination with alternative therapies. (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic) (PARP) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic) DNA (sic)(sic),(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic). PARP (sic)(sic)(sic) (PARPi) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic) DNA (sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic) (HRD) (sic)(sic)(sic)(sic). (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic),(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic). (sic)(sic) PARPi (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic). (sic)(sic)(sic)(sic)(sic) PARPi (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic) PARPi (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic).

分类号：

  • 相关文献

[1]Prevalence and underlying mechanisms of phylosymbiosis in land plants. Lin, Li-Qun,Tembrock, Luke R.,Wang, Li. 2024

[2]Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation. Zheng, Jiangge,Lang, Yue,Zhang, Qi,Cui, Di,Sun, Haili,Jiang, Lun,Chen, Zhenhang,Zhang, Rui,Gao, Yina,Wu, Wei,Tang, Jun,Chen, Zhongzhou,Lang, Yue,Cui, Di,Sun, Haili,Zhang, Rui,Tang, Jun,Tian, Wenli.

[3]Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation. Gao, Yina,Liu, Yang,Dong, Xiaofei,Chen, Zhenhang,Tang, Jun,Wu, Wei,Chen, Zhongzhou,Zhang, Qi,Tong, Yufeng,Lang, Yue,Tang, Jun,Tian, Wenli,Tong, Yufeng.

[4]Recent Advances in Developing Photosensitizers for Photodynamic Cancer Therapy. Chen, Cong,Wang, Jianmin,Li, Xiaoyan,Chen, Cong,Wang, Jianmin,Li, Xiaoyan,Liu, Xiaolong,Liu, Xiaolong,Han, Xiao.

[5]The Coronin Family and Human Disease. Liu, Xiaolong,Gao, Yunzhen,Li, Lin,Liu, Jingfeng,Lin, Xiao,Li, Lin,Liu, Jingfeng,Han, Xiao.

[6]A review of recent studies in China on the possible beneficial health effects of tea. Zhu, YX,Huang, H,Tu, YY. 2006

[7]Tea and human health: biomedical functions of tea active components and current issues. Chen, Zong-mao,Lin, Zhi. 2015

[8]Quantification of pegylated liposomal doxorubicin and doxorubicinol in rat plasma by liquid chromatography/electro spray tandem mass spectroscopy: Application to preclinical pharmacokinetic studies. Yang, Yuhui,Liu, Yanhong,Liu, Xiangtao,Jiang, Tao.

[9]Protocol to assess the antitumor efficacy of an immunotherapeutic peptide in syngeneic orthotopic glioma mouse models. Apeng Chen,Yapeng Chao,Han Zou,Lauren H. McCarl,Gary Kohanbash,Baoli Hu. 2023

[10]Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells. Xianjin Kan,Yuncong Yin,Cuiping Song,Lei Tan,Xusheng Qiu,Ying Liao,Weiwei Liu,Songshu Meng,Yingjie Sun,Chan Ding. 2021

[11]Research Progress on the Structure and Function of G3BP. Weifang Kang,Yue Wang,Wenping Yang,Jing Zhang,Haixue Zheng,Dan Li. 2021

[12]Health functions and related molecular mechanisms of ellagitannin-derived urolithins. Gandhi, Gopalsamy Rajiv,Antony, Poovathumkal James,Ceasar, Stanislaus Antony,Silva Vasconcelos, Alan Bruno,Montalvao, Monalisa Martins,Farias de Franca, Mariana Nobre,Resende, Ayane de Sa,Sharanya, Chelankara Suresh,Liu, Yi,Hariharan, Govindasamy,Gan, Ren-You. 2022

[13]Dietary sources, health benefits, and risks of caffeine. Saimaiti, Adila,Zhou, Dan-Dan,Li, Jiahui,Xiong, Ruo-Gu,Gan, Ren-You,Huang, Si-Yu,Shang, Ao,Zhao, Cai-Ning,Li, Hang-Yu,Li, Hua-Bin. 2022

[14]Micrornas, T-Cell Immunity And Immunotherapy .. Giri, BR, Cheng, GF. 2019

[15]Piceatannol, a Dietary Polyphenol, Alleviates Adipose Tissue Loss in Pre-Clinical Model of Cancer-Associated Cachexia via Lipolysis Inhibition. Kershaw, Jonathan C.,Elzey, Bennett D.,Guo, Xiao-Xuan,Kim, Kee-Hong. 2022

[16]Interplay Between Mirnas And Host G.enes And Their Role I n Cancer. Liu, BH,Shyr, Y,Cai, JP,Liu, Q. 2019

[17]Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Daniel J. Klionsky,Amal Kamal Abdel-Aziz,Sara Abdelfatah,Mahmoud Abdellatif,Asghar Abdoli,Steffen Abel,Hagai Abeliovich,Marie H. Abildgaard,Yakubu Princely Abudu,Abraham Acevedo-Arozena,Iannis E. Adamopoulos,Khosrow Adeli,Timon E. Adolph,Annagrazia Adornetto,Elma Aflaki,Galila Agam,Anupam Agarwal,Bharat B. Aggarwal,Maria Agnello,Patrizia Agostinis,Javed N. Agrewala,Alexander Agrotis,Patricia V. Aguilar,S. Tariq Ahmad,Zubair M. Ahmed,Ulises Ahumada-Castro,Sonja Aits,Shu Aizawa,Yunus Akkoc,Tonia Akoumianaki,Hafize Aysin Akpinar,Ahmed M. Al-Abd,Lina Al-Akra,Abeer Al-Gharaibeh,Moulay A. Alaoui-Jamali,Simon Alberti,Elísabet Alcocer-Gómez,Cristiano Alessandri,Muhammad Ali,M. Abdul Alim Al-Bari,Saeb Aliwaini,Javad Alizadeh,Eugènia Almacellas,Alexandru Almasan,Alicia Alonso,Guillermo D. Alonso,Nihal Altan-Bonnet,Dario C. Altieri,Élida M.C. Álvarez,Sara Alves,Cristine Alves da Costa,Mazen M. Alzaharna,Marialaura Amadio,Consuelo Amantini,Cris. 2021

[18]Honey Bee Products: Preclinical and Clinical Studies of Their Anti-inflammatory and Immunomodulatory Properties. Hesham R. El-Seedi,Nehal Eid,Aida A. Abd El-Wahed,Mostafa E. Rateb,Hanan S. Afifi,Ahmed F. Algethami,Chao Zhao,Yahya Al Naggar,Sultan M. Alsharif,Haroon Elrasheid Tahir,Baojun Xu,Kai Wang,Shaden A.M. Khalifa. 2022

[19]Senecavirus A as an Oncolytic Virus: Prospects, Challenges and Development Directions. Dankun Luo,Haiwei Wang,Qiang Wang,Wenping Liang,Bo Liu,Dongbo Xue,Yang Yang,Biao Ma. 2022

[20]Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis. Yue Kong,Yugeng Liu,Xianzhe Li,Menglan Rao,Dawei Li,Xiaolan Ruan,Shanglin Li,Zhenyou Jiang,Qiang Zhang. 2023

作者其他论文 更多>>