数字农科院2.0

Enhanced brain-targeting and efficacy of cannabidiol via RVG-Exo/CBD nanodelivery system

文献类型： 外文期刊

作者： Yingrui Li;Ze Chen;Jia Guo;Deshuang Meng;Xin Pang;Zepeng Sun;Li Pu;Shuiyue Yang;Min Yang;Yinghua Peng

作者机构：

关键词： Brain-targeted delivery;Cannabidiol;Drug delivery;Exosomes;RVG

期刊名称： Biochemical and Biophysical Research Communications

ISSN： 0006-291X

年卷期： 2024 年 725 卷

页码：

收录情况： SCIE（2024版）

摘要： This study introduces an innovative brain-targeted drug delivery system, RVG-Exo/CBD, utilizing rabies virus glycoprotein (RVG)-engineered exosomes for encapsulating cannabidiol (CBD). The novel delivery system was meticulously characterized, confirming the maintenance of exosomal integrity, size, and successful drug encapsulation with a high drug loading rate of 83.0 %. Evaluation of the RVG-Exo/CBD's brain-targeting capability demonstrated superior distribution and retention in brain tissue compared to unmodified exosomes, primarily validated through in vivo fluorescence imaging. The efficacy of this delivery system was assessed using a behavioral sensitization model in mice, where RVG-Exo/CBD notably suppressed methamphetamine-induced hyperactivity more effectively than CBD alone, indicating a reduction in effective dose and enhanced bioavailability. Overall, the RVG-Exo/CBD system emerges as a promising strategy for enhancing the therapeutic efficacy and safety of CBD, particularly for neurological applications, highlighting its potential for addressing the limitations associated with traditional CBD administration in clinical settings.

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