数字农科院2.0

Dietary Mannan-Rich Fractions Attenuate Weaning Stress in Piglets via Modulating Gut Microbiota and TLR5/NF-κB Signaling

文献类型： 外文期刊

作者： Lu, Yutong;Sun, Yiwei;Cai, Kun;He, Pingli;Lin, Gang;Qi, Zengkai;Liu, Hu;Yan, Junshu;Ma, Ning

作者机构：

关键词： intestinal inflammation;mannan-rich fraction (MRF);NF-kappa B;piglet weaning diarrhea;TLR5

期刊名称： ANIMAL RESEARCH AND ONE HEALTH

ISSN： 2835-5075

年卷期： 2025 年

页码：

收录情况： 无来源刊（2025版）

摘要： Addressing weaning stress in modern swine production requires dietary interventions that improve gut health and reduce antibiotic use. It is crucial for sustainable animal husbandry, public health and environmental protection. The mannan-rich fraction (MRF), a prebiotic, is known to modulate the intestinal microbiota. However, its effects on regulating intestinal flora and the potential mechanisms for alleviating diarrhea and weaning stress in piglets remain incompletely defined. Herein, we investigated the effects of dietary MRF supplementation on growth performance, intestinal morphology, gut microbiota composition, and inflammatory responses in Duroc x Large x White weaned piglets. MRF reduced the incidence of diarrhea to the same extent as antibiotics (p < 0.01). Compared with control group, MRF-fed piglets exhibited increased ileal villus height (p < 0.01), higher abundance of Prevotella and Roseburia, and lower Campylobacter abundance (p < 0.01). MRF also elevated hindgut short-chain fatty acids (SCFAs) concentrations, especially butyrate (p < 0.01). Mechanistically, molecular docking and transcriptomic analyses indicated that MRF can interact with Toll-like receptor 5 (TLR5), thereby destabilizing the TLR5-NF-kappa B p65 complex. This interactions attenuated the phosphorylation of NF-kappa B p65 (p < 0.01) and down-regulated transcription of IL-1 beta in the colon (p < 0.05). Collectively, our results demonstrate that MRF reshapes the gut microbiota, enhances barrier function, and potentially suppresses TLR5/NF-kappa B-mediated inflammation, offering a strategy to reduce antibiotic use in promoting piglet intestinal health.

分类号：

  • 相关文献

[1]Flagellin As A Vaccine Adjuvant .. Cui, BF,Liu, XS,Fang, YZ,Zhou, P,Zhang, YG,Wang, YL. 2018

[2]Dietary organic acids ameliorate high stocking density stress-induced intestinal inflammation through the restoration of intestinal microbiota in broilers. Dong Dai,Guanghai Qi,Jing Wang,Haijun Zhang,Kai Qiu,Yanming Han,Yuanyuan Wu,Shugeng Wu. 2022

[3]Dietary Bacillus licheniformis shapes the foregut microbiota, improving nutrient digestibility and intestinal health in broiler chickens. Yunsheng Han,Xin Xu,Jiaxin Wang,Hongying Cai,Daojie Li,Hongwei Zhang,Peilong Yang,Kun Meng. 2023

[4]Metagenomic insights into the composition and function of the gut microbiota of mice infected with Toxoplasma gondii. Jin Xin Meng,Xin Yu Wei,Huanping Guo,Yu Chen,Wei Wang,Hong Li Geng,Xing Yang,Jiang Jiang,Xiao Xuan Zhang. 2023

[5]Algal oil alleviates antibiotic-induced intestinal inflammation by regulating gut microbiota and repairing intestinal barrier. Zhang H.,Xu Z.,Chen W.,Huang F.,Chen S.,Wang X.,Yang C.. 2023

[6]Synthesis and antibacterial activity of FST and its effects on inflammatory response and intestinal barrier function in mice infected with Escherichia coli O78. Ge W.,Li Z.,Yang Y.,Liu X.,Zhu Z.,Bai L.,Qin Z.,Xu X.,Li J.,Li S.. 2024

[7]Editorial: Functional feed additives and intestinal health in aquatic animals. Gang Yang,Zhen Zhang,Vikash Kumar. 2024

[8]Effect of dietary aspirin eugenol ester on the growth performance, antioxidant capacity, intestinal inflammation, and cecal microbiota of broilers under high stocking density. Haojie Zhang,Yi Zhang,Dongying Bai,Jiale Zhong,Xiaodi Hu,Ruilin Zhang,Wenrui Zhen,Koichi Ito,Bingkun Zhang,Yajun Yang,Jianyong Li,Yanbo Ma. 2024

[9]Strain specificity of lactobacilli with promoted colonization by galactooligosaccharides administration in protecting intestinal barriers during Salmonella infection. Wu, Yujun,Zhang, Xiangyu,Liu, Xiaoyi,Li, Yi,Han, Dandan,Pi, Yu,Whitmore, Melanie A.,Lu, Xingmiao,Zhang, Guolong,Zheng, Jinkai,Wang, Junjun. 2024

[10]Gut Microbiota Alleviates Intestinal Injury Induced by Extended Exposure to Light via Inhibiting the Activation of NLRP3 Inflammasome in Broiler Chickens. Dandan Ma,Minhong Zhang,Jinghai Feng. 2024

[11]Rosemary (Rosmarinus officinalis L.) polyphenols and inflammatory bowel diseases: Major phytochemicals, functional properties, and health effects. Lianhua Zhang,Jie Lu. 2024

[12]Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus. Zhang, Shunfen,Zhong, Ruqing,Zhou, Miao,Li, Kai,Lv, Huiyuan,Wang, Huixin,Xu, Ye,Liu, Dadan,Ma, Qiugang,Chen, Liang,Zhang, Hongfu. 2025

[13]A Novel Synbiotic Protects Against DSS-Induced Colitis in Mice via Anti-inflammatory and Microbiota-Balancing Properties. Yang, Yong,Qiao, Yuyu,Liu, Ge,Chen, Weihao,Zhang, Ting,Liu, Jing,Fan, Weiping,Tong, Mingwei. 2024

[14]Baicalin alleviates intestinal inflammation and microbial disturbances by regulating Th17/Treg balance and enhancing Lactobacillus colonization in piglets. Shunfen Zhang,Chengzeng Luo,Kai Li,Junhong Wang,Huixin Wang,Ruqing Zhong,Liang Chen,Qiugang Ma,Hongfu Zhang. 2024

[15]Protective effect of a newly probiotic Lactobacillus reuteri LY2-2 on DSS-induced colitis. Yang, Yong,Qiao, Yuyu,Liu, Ge,Yi, Gaoqin,Liu, Hongli,Zhang, Ting,Tong, Mingwei. 2025

[16]Dietary Fagopyrum dibotrys Extract Supplementation: Impacts on Growth Performance, Immune Response, Intestinal Morphology, and Microbial Community in Broiler Chickens Infected with Escherichia coli O157. Jiang Chen,Gaoxiang Ai,Pingwen Xiong,Wenjing Song,Guohua Liu,Qipeng Wei,Xiaolian Chen,Zhiheng Zou,Qiongli Song. 2025

[17]Pectic polysaccharides from unripe and mature kiwifruit alleviate ulcerative colitis by modulating gut microbiota and restoring the intestinal barrier. Kai Xin Jiang,Jin Lei Geng,Qin Yuan,Jie Li,Wen Liu,Hong Yan Liu,Yi Chen Hu,Liang Zou,Shengpeng Wang,Ding Tao Wu. 2025

[18]Limosilactobacillus reuteri SXDT-32-derived shikimic acid protects against colonic inflammation in piglets by inhibiting the PI3K-Akt pathway. Ying Chen,Chengzeng Luo,Zhaohan Zhan,Shuo Liu,Chunran Teng,Ruixiao Mao,Shunfen Zhang,Xunbozan Zhang,Qingshi Meng,Ruqing Zhong,Liang Chen,Hongfu Zhang. 2025

[19]Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-kappa B activation. Zhao, Zhanzhong,Tang, Xiangfang,Zhang, Minhong,Hou, Shaohua,Yuan, Weifeng,Zhang, Hongfu,Shi, Lijun,Jia, Hong,Liang, Lin,Zhao, Zhanzhong,Zhao, Xinghui,Fu, Ling,Chen, Wei,Zhang, Weijian,Lai, Zhi,Gao, Junfeng,Zhang, Keyu. 2014

[20]Influence of acrylamide on ROS, Hsp27 and NF-kappa B in bone marrow mesenchymal stem cells. Liu, Yang,Tao, Xiaoli,Mu, Yulian,Wang, Pan,Feng, Shutang,Li, Kui,Liu, Yang,Mu, Yulian,Wang, Pan,Feng, Shutang,Li, Kui,Liu, Yang,Mu, Yulian,Wang, Pan,Feng, Shutang,Li, Kui,Tao, Xiaoli.

作者其他论文 更多>>