数字农科院2.0

Chromatographic and Mass Spectroscopic Guided Discovery of Trichoderma Peptaibiotics and their Bioactivity

文献类型： 外文期刊

作者： Adigo Setargie;Chen Wang;Liwen Zhang;Yuquan Xu

作者机构：

关键词： Chromatography;peptaibiotics;spectroscopy;Trichoderma

期刊名称： Engineering Microbiology

ISSN： 2667-3703

年卷期： 2024 年 4 卷 2 期

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收录情况： 无来源刊（2024版）

摘要： Peptaibiotics are linear or cyclic peptide antibiotics characterized by the non-proteinogenic amino acid, alpha-aminoisobutyric acid. They exhibit a wide range of bioactivity against various pathogens. This report presents a comprehensive review of analytical methods for Trichoderma cultivation, production, isolation, screening, purification, and characterization of peptaibiotics, along with their bioactivity. Numerous techniques are currently available for each step, and we focus on describing the most commonly used and recently developed chromatographic and spectroscopic techniques. Investigating peptaibiotics requires efficient culture media, growth conditions, and isolation and purification techniques. The combination of chromatographic and spectroscopic tools offers a better opportunity for characterizing and identifying peptaibiotics. The evaluation of the chemical and biological properties of this compound has also been explored concerning its potential application in pharmaceutical and other industries. This review aims to summarize available data on the techniques and tools used to screen and purify peptaibiotics from Trichoderma fungi and bioactivity against various pathogens.

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