数字农科院2.0

Edible ginseng-derived exosomes as drug delivery vehicles reduce the dose and improve the anti-cancer effect of CDDP

文献类型： 外文期刊

作者： Shuiyue Yang;Jia Guo;Shan Huang;Zepeng Sun;Min Yang;Yinghua Peng

作者机构：

关键词： Cancer treatment;Cisplatin;Drug delivery;Exosomes;Ginseng

期刊名称： Biochemical and Biophysical Research Communications

ISSN： 0006-291X

年卷期： 2025 年 758 卷

页码：

收录情况： SCIE（2025版）

摘要： Nanotechnology and nanomaterials have emerged as promising tools for the delivery of anti-tumor drug cisplatin (CDDP). However, concerns exist regarding potential toxicity and cost-effectiveness, limiting their clinical applications. In contrast, plant-derived exosomes (PDEs), as natural nanovesicles, offer significant advantages as drug delivery carriers due to their large-scale production, biocompatibility, and ability to efficiently transport therapeutic drug across cellular barriers. In this work, we established a ginseng-derived exosome (G-Exo)-based CDDP delivery system (G-CDDP) and evaluated its anti-tumor efficacy both in vitro and in vivo. The results demonstrated that G-CDDP effectively targeted tumor site, inhibiting the proliferation and migration and promoting apoptosis in U-87MG tumor cells. Notably, the amount of CDDP in G-CDDP required for achieving the same cytotoxic effect on tumor cells was 12.66 times lower than that of free CDDP. In U-87MG tumor-bearing mice, G-CDDP effectively targeted tumor sites and exhibited significant therapeutic effect. Collectively, these findings highlight the potent anti-tumor activity of G-CDDP at reduced CDDP dosage, positioning it as a promising and efficient alternative to conventional drug treatments in clinical settings.

分类号：

  • 相关文献

[1]Enhanced brain-targeting and efficacy of cannabidiol via RVG-Exo/CBD nanodelivery system. Yingrui Li,Ze Chen,Jia Guo,Deshuang Meng,Xin Pang,Zepeng Sun,Li Pu,Shuiyue Yang,Min Yang,Yinghua Peng. 2024

[2]Early responses of the STAT3 pathway to platinum drugs are associated with cisplatin resistance in epithelial ovarian cancer. Sheng, W. J.,Jiang, H.,Zheng, J. H.,Wu, D. L.. 2013

[3]Silencing of BAG3 promotes the sensitivity of ovarian cancer cells to cisplatin via inhibition of autophagy. Qiu, Shuang,Jin, Ye,An, Qi,Zheng, Jianhua,Sun, Liang,Weng, Changjiang.

[4]Polysaccharide from Sepia esculenta ink and cisplatin inhibit synergistically proliferation and metastasis of triple-negative breast cancer MDA-MB-231 cells. Liu, Hua-Zhong,Xiao, Wei,Shang, Jiang-Hua,Xiao, Wei,Zhang, Da-Yan,Gu, Yi-Peng,Tao, Ye-Xing,Du, Hui. 2016

[5]Platycodin D restores the intestinal mechanicalbarrier by reducing endoplasmic reticulum stress-mediated apoptosis. Fan M.-L.,Wei K.,Wei X.-M.,Zhang J.-J.,Hou J.-G.,Shen Q.,Sun Y.-S.,Li X.-D.,Wang Z.,Jiao L.-L.,Li W.. 2022

[6]Kidney Protection Effect Of Ginsenoside R.e And Its Underlying M echanisms On Cisplatin-Induced Kidney Injury. Wang, Z, Li, YF, Han, XY, Sun, YS, Zhang, LX, Liu, W, Liu, XX, Li, W, Liu, YY. 2018

[7]Based on network pharmacology and molecular docking to explore the protective effect of Epimedii Folium extract on cisplatin-induced intestinal injury in mice. Xia J.,Hu J.-N.,Wang Z.,Cai E.-B.,Ren S.,Wang Y.-P.,Lei X.-J.,Li W.. 2022

[8]Exploration of the protective mechanisms of Icariin against cisplatin-induced renal cell damage in canines. Liu, Jiayi,Xie, Liuwei,Zhai, He,Wang, Dongwei,Li, Xiao,Wang, Yao,Song, Mingqiang,Xu, Chao. 2024

[9]Polyacrylic Acid-Coated Selenium-Doped Carbon Dots Inhibit Ferroptosis to Alleviate Chemotherapy-Associated Acute Kidney Injury. Li, Jiahuan,Fu, Chengcheng,Feng, Baoli,Liu, Qingquan,Gu, Jiangjiang,Khan, Mohammad Nauman,Sun, Lvhui,Wu, Honghong,Wu, Hao. 2024

[10]The Cardioprotective Effect of Ginseng Derived Exosomes via Inhibition of Oxidative Stress and Apoptosis. Yang, Shuiyue,Guo, Jia,Chen, Danyang,Sun, Zepeng,Pu, Li,Sun, Guoying,Yang, Min,Peng, Yinghua. 2024

[11]The application of virus-like particles as vaccines and biological vehicles. Yan, Dan,Wei, Yan-Quan,Guo, Hui-Chen,Sun, Shi-Qi,Yan, Dan,Wei, Yan-Quan,Guo, Hui-Chen,Sun, Shi-Qi.

[12]Foot-And-Mouth Disease Virus-Like Particles As I.ntegrin-Based Drug Delivery System A chieve Targeting Anti-Tumor Efficacy. Yan, D,Teng, ZD,Sun, SQ,Jiang, S,Dong, H,Gao, Y,Wei, YQ,Qin, WW,Liu, XT,Yin, H,Guo, HC. 2017

[13]Self-assembled thiophanate-methyl/star polycation complex prevents plant cell-wall penetration and fungal carbon utilization during cotton infection by Verticillium dahliae. Xiaofeng Su,Shuo Yan,Weisong Zhao,Haiyang Liu,Qinhong Jiang,Ying Wei,Huiming Guo,Meizhen Yin,Jie Shen,Hongmei Cheng. 2023

[14]Self-Assembled Nanonematicide Induces Adverse Effects on Oxidative Stress, Succinate Dehydrogenase Activity, and ATP Generation. Peng, Huan,Jian, Jinzhuo,Long, Haibo,Jiang, Qinhong,Huang, Wenkun,Kong, Lingan,Yin, Meizhen,Shen, Jie,Su, Xiaofeng,Peng, Deliang,Yan, Shuo. 2023

[15]Multi-templates molecularly imprinted polymers for simultaneous recognition of multiple targets: From academy to application. Shenling Wang,Le Zhang,Jing Zeng,Xiaofeng Hu,Xiupin Wang,Li Yu,Du Wang,Ling Cheng,Rajib Ahmed,Valentin Romanovski,Peiwu Li,Zhaowei Zhang. 2023

[16]Polyphenolic Nanomedicine Regulating Mitochondria REDOX for Innovative Cancer Treatment. Mingchuan Yang,Yufeng He,Qingqing Ni,Mengxue Zhou,Hongping Chen,Guangyun Li,Jizhong Yu,Ximing Wu,Xiangchun Zhang. 2024

[17]Preparation of salicylic acid nano-protectant with dual synergistic mechanism: High direct fungicidal activity and plant defence toward cotton Verticillium wilt. Jiaming Yin,Jiajia Zhao,Zeng Wang,Fan Xue,Qi Wang,Huiming Guo,Hongmei Cheng,Jie Li,Jie Shen,Meizhen Yin,Xiaofeng Su,Shuo Yan. 2024

[18]Current and emerging applications of saccharide-modified chitosan: a critical review. Hamed Kazemi Shariat Panahi,Mona Dehhaghi,Hamid Amiri,Gilles J. Guillemin,Vijai Kumar Gupta,Ahmad Rajaei,Yadong Yang,Wanxi Peng,Junting Pan,Mortaza Aghbashlo,Meisam Tabatabaei. 2023

[19]Optimizing the Size of Zr-Based Metal-Organic Frameworks for Enhanced Anticancer Efficacy. Cheng, Zan,Yu, Mei,Wan, Yilong,Xiang, Huandong,Wei, Haoran,Zu, Xu,Li, Xin,Zhang, Ruiting,Li, Fangshu,Wang, Shanshan,She, Yongxin. 2025

[20]Preparation of a Fluxapyroxad Nanoformulation with Strong Plant Uptake for Efficient Control of Verticillium Wilt in Potato. Wang, Dong,Weng, Huiting,Zhao, Yuanzheng,Zhou, Hongyou,Guo, Huiming,程红梅、Shen, Jie,Yin, Meizhen,Yan, Shuo,Su, Xiaofeng. 2025

作者其他论文 更多>>