数字农科院2.0

Alginate Oligosaccharides Repair Liver Injury by Improving Anti-Inflammatory Capacity in a Busulfan-Induced Mouse Model

文献类型： 外文期刊

作者： Yanan Hao;Hanhan Fang;Xiaowei Yan;Wei Shen;Jing Liu;Pengfei Han;Yong Zhao;Weidong Zhang;Yanni Feng

作者机构：

关键词： AOS;blood metabolites;inflammation;liver diseases

期刊名称： International journal of molecular sciences

ISSN： 1422-0067

年卷期： 2023 年 24 卷 4 期

页码：

收录情况： SCIE（2023版）

摘要： Liver diseases are associated with many factors, including medicines and alcoholics, which have become a global problem. It is crucial to overcome this problem. Liver diseases always come with inflammatory complications, which might be a potential target to deal with this issue. Alginate oligosaccharides (AOS) have been demonstrated to have many beneficial effects, especially anti-inflammation. In this study, 40 mg/kg body weight (BW) of busulfan was intraperitoneally injected once, and then the mice were dosed with ddH2O or AOS 10 mg/kg BW every day by oral gavage for five weeks. We investigated AOS as a potential no-side-effect and low-cost therapy for liver diseases. For the first time, we discovered that AOS 10 mg/kg recovered liver injury by decreasing the inflammation-related factors. Moreover, AOS 10 mg/kg could improve the blood metabolites related to immune and anti-tumor effects, and thus, ameliorated impaired liver function. The results indicate that AOS may be a potential therapy to deal with liver damage, especially in inflammatory conditions.

分类号：

  • 相关文献

[1]Alginate oligosaccharides ameliorate busulfan-induced renal tubule injury. Xiaowei Yan,Xiangping Ma,Yanan Hao,Jing Liu,Hanhan Fang,Dongxin Lu,Wei Shen,Hongfu Zhang,Wei Ge,Yong Zhao. 2022

[2]Alginate Oligosaccharides Improve Germ Cell Development And Testicular Microenvironment To Rescue Busulfan Disrupted Spermatogenesis. Zhao, Y, Zhang, PF, Ge, W, Feng, YN, Li, L, Sun, ZY, Zhang, HF, Shen, W. 2020

[3]Gut Microbiota-Testis Axis: FMT Mitigates High-Fat Diet-Diminished Male Fertility via Improving Systemic and Testicular Metabolome. Hao, Yanan,Feng, Yanni,Yan, Xiaowei,Chen, Liang,Ma, Xiangping,Tang, Xiangfang,Zhong, Ruqing,Sun, Zhongyi,Agarwal, Manjree,Zhang, Hongfu,Zhao, Yong. 2022

[4]A combination of flaxseed oil and astaxanthin alleviates atherosclerosis risk factors in high fat diet fed rats. Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Huang, Fenghong,Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Huang, Fenghong,Gao, Hui,Yang, Wei,Zhang, Li,Chen, Chang,Chen, Chang. 2014

[5]Flaxseed lignan secoisolariciresinol diglucoside ameliorates experimental colitis induced by dextran sulphate sodium in mice. Xu, Jiqu,Tian, Guangjing,Ma, Congcong,Deng, Qianchun,Huang, Qingde,Huang, Fenghong,Xu, Jiqu,Tian, Guangjing,Ma, Congcong,Deng, Qianchun,Huang, Qingde,Huang, Fenghong,Gao, Hui,Yang, Wei,Chen, Chang,Chen, Chang,Ma, Zhonghua.

[6]Enhanced Anti-Inflammatory Activities by the Combination of Luteolin and Tangeretin. Funaro, Antonietta,Wu, Xian,Song, Mingyue,Zheng, Jinkai,Guo, Shanshan,Rakariyatham, Kanyasiri,Xiao, Hang,Funaro, Antonietta,Rodriguez-Estrada, Maria Teresa,Xiao, Hang,Zheng, Jinkai,Guo, Shanshan. 2016

[7]Fibroblast growth factor 21 (FGF21) ameliorates collagen-induced arthritis through modulating oxidative stress and suppressing nuclear factor-kappa B pathway. Yu, Yinhang,Li, Siming,Liu, Yaonan,Tian, Guiyou,Yuan, Qingyan,Bai, Fuliang,Wang, Wenfei,Ren, Guiping,Li, Deshan,Wang, Wenfei,Ren, Guiping,Li, Deshan,Zhang, Yu,Zhang, Zhiyi,Li, Siming. 2015

[8]n-6: n-3 PUFA ratio is involved in regulating lipid metabolism and inflammation in pigs. Duan, Yehui,Li, Fengna,Li, Lili,Sun, Xiaoming,Yin, Yulong,Duan, Yehui,Fan, Juexin,Sun, Xiaoming. 2014

[9]Influence of dietary taurine and housing density on oviduct function in laying hens. Dai, Bin,Zhang, Yuan-shu,Zheng, Liu-hai,Li, Shuang-jie,Miao, Jin-feng,Ma, Zi-li,Dou, Xin-hong,Gong, Jian-sen. 2015

[10]Staphylococcus aureus infection of intestinal epithelial cells induces human umbilical cord-derived mesenchymal stem cell migration. Li, Yang,Liu, Ming-yuan,Wang, Xue-lin,Han, Wen-yu,Liu, Ya-hui,Suo, Jian,Li, Zhi-jie,Li, Ya-gang,Jin, Hu. 2013

[11]Effect of Candida albicans on Intestinal Ischemia-reperfusion Injury in Rats. Yan, Lei,Wu, Chun-Rong,Yang, Chun-Hui,Tang, Jian-Guo,Wang, Chen,Tong, Guang-Zhi. 2016

[12]Expression and characterization of recombinant gallinacin-9 and gallinacin-8 in Escherichia coli. Ma, De-ying,Shan, An-shan,Liu, Sheng-wang,Han, Zong-xi,Li, Yi-jin.

[13]Protective Effects of Genistein and Puerarin against Chronic Alcohol-Induced Liver Injury in Mice via Antioxidant, Anti-inflammatory, and Anti-apoptotic Mechanisms. Zhao, Liang,Wang, Yong,Guo, Xiaoxuan,Ji, Baoping,Zhou, Feng,Liu, Jia,Wang, Kai,Wu, Wei.

[14]PLC-gamma 1 is involved in the inflammatory response induced by influenza A virus H1N1 infection. Xu, Shuai,Yang, Jiayun,Zhu, Qiyun,Zhu, Liqian,Yuan, Chen,Ding, Xiuyan,Zhu, Liqian,Yuan, Chen,Ding, Xiuyan,Liang, Yuying.

[15]Flaxseed oil and alpha-lipoic acid combination reduces atherosclerosis risk factors in rats fed a high-fat diet. Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Yang, Jin'e,Huang, Fenghong,Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Yang, Jin'e,Huang, Fenghong,Yang, Wei. 2012

[16]Optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats. Xu, Jiqu,Ma, Congcong,Han, Ling,Zhou, Qi,Yang, Mei,Deng, Qianchun,Huang, Qingde,Huang, Fenghong,Xu, Jiqu,Ma, Congcong,Han, Ling,Zhou, Qi,Yang, Mei,Deng, Qianchun,Huang, Qingde,Huang, Fenghong,Gao, Hui,Chen, Chang,Chen, Chang. 2014

[17]Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet. Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Yang, Jin'e,Huang, Fenghong,Zhou, Xiaoqi. 2011

[18]Identification of porcine serum proteins modified in response to HP-PRRSV HuN4 infection by two-dimensional differential gel electrophoresis. An, Tongqing,Gong, Daqing,Peng, Jinmei,Leng, Chaoliang,Yuan, Zhonghua,Tian, Zhijun,Yang, Yongqian,Li, Dengyun,Zhang, Deli,Tong, Guangzhi. 2012

[19]Protective Effect of Total Flavones from Hippophae rhamnoides L. against Visible Light-Induced Retinal Degeneration in Pigmented Rabbits. Wang, Yong,Zhao, Liang,Wang, Ou,Guo, Xiaoxuan,Lu, Feng,Yang, Xue,Ji, Baoping,Huang, Fenghong,Deng, Qianchun,Huang, Fenghong,Deng, Qianchun,Zhang, Di.

[20]Flaxseed oil containing flaxseed oil ester of plant sterol attenuates high-fat diet-induced hepatic steatosis in apolipoprotein-E knockout mice. Han, Hao,Ma, Hongfei,Rong, Shuang,Chen, Li,Shan, Zhilei,Liu, Liegang,Han, Hao,Ma, Hongfei,Rong, Shuang,Chen, Li,Shan, Zhilei,Liu, Liegang,Xu, Jiqu,Zhang, Yunjian.

作者其他论文 更多>>