数字农科院2.0

Unveiling hidden risks of chiral fungicide benzovindiflupyr: Stereoselectivity in soil antibiotic resistance gene transmission

文献类型： 外文期刊

作者： Xin Zhang;Yanni Feng;Xiaoke Jiang;Wei Sun;Chengzhi Zhang;Jie Han;Yuqing Hou;Xiangwei You;Houpu Zhang;Xiuguo Wang;Xiangwei Wu;Jun Wang

作者机构：

关键词： Chiral pesticide;Ecological risk;Environmental fate;Metagenome;Stereoselectivity

期刊名称： Journal of Hazardous Materials

ISSN： 0304-3894

年卷期： 2026 年 503 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Antibiotic resistance gene (ARG) dissemination is closely associated with modern agricultural practices. However, the stereoselective effects of widely applied chiral pesticides on resistance evolution remain insufficiently investigated. This study systematically explored the differential effects of benzovindiflupyr enantiomers on transmission of ARGs through long-term soil incubation experiments combined with metagenomic and in vitro studies. Results demonstrated that 1S,4R-enantiomer exhibited significantly longer half-life than 1 R,4S-enantiomer. 1 R,4S-enantiomer induced extreme enrichment of a few ARGs. 1S,4R-enantiomer persistently increased abundance of multiple ARGs. Compared with 1 R,4S-enantiomer, 1S,4R-enantiomer more consistently enhanced abundance of mobile genetic elements (MGEs) related to conjugative transfer. Moreover, 1 R,4S-enantiomer primarily enriched specific genera within Pseudomonadota. 1S,4R-enantiomer simultaneously promoted abundance of multiple genera across both Pseudomonadota and Bacteroidota, driving cross-phylum genera to correlate with shared ARGs. Genomic analysis confirmed that Pseudomonadota under 1S,4R-enantiomer treatment carried more ARGs and MGEs. In vitro transformation experiments ultimately validated that 1S,4R-enantiomer significantly enhanced transformation efficiency across multiple ARGs consistently, substantially exceeding 1 R,4S-enantiomer effects. Overall, 1S,4R-enantiomer poses more significant risks for horizontal transfer of ARGs. This study elucidates enantioselective effects of chiral pesticides on transmission of ARGs, providing a foundation for improving chiral agrochemical risk assessment.

分类号：

  • 相关文献

[1]Direct Enantioseparation of Nitrogen-Heterocyclic Pesticides on Cellulose-Based Chiral Column by High-Performance Liquid Chromatography. Chai, Tingting,Yang, Wenwen,Hou, Shicong,Chai, Tingting,Yang, Wenwen,Qiu, Jing.

[2]Direct enantioseparation of nitrogen-heterocyclic pesticides on amylose-tris-(5-chloro-2-methylphenylcarbamate) by reversed-phase high-performance liquid chromatography. Yang, Wenwen,Qiu, Jing,Chen, Tianjin,Yang, Shuming,Yang, Wenwen,Qiu, Jing,Chen, Tianjin,Yang, Shuming,Yang, Wenwen,Hou, Shicong.

[3]Wheat straw pyrochar more efficiently decreased enantioselective uptake of dinotefuran by lettuce and dissemination of antibiotic resistance genes than pyrochar in an agricultural soil. Yadong Cheng,Xiao Wang,Liuwei Zhao,Xin Zhang,Qingxian Kong,Hui Li,Xiangwei You,Yiqiang Li. 2023

[4]Quantitative determination of fullerene (C-60) in soils by high performance liquid chromatography and accelerated solvent extraction technique. Shareef, Ali,Kookana, Rai S.,Li, Guihua. 2010

[5]Chiral Fungicide Famoxadone: Stereoselective Bioactivity, Aquatic Toxicity, and Environmental Behavior in Soils. Guofeng Xu,Xiaohui Jia,Chi Wu,Xingang Liu,Fengshou Dong. 2021

[6]Sorption and degradation of prothioconazole and its metabolites in soils and water sediments, and its combinative toxicity to Gobiocypris rarus. Chi Wu,Lan Zhang,Liangang Mao,Lizhen Zhu,Yanning Zhang,Hongyun Jiang,Yongquan Zheng,Xingang Liu. 2022

[7]From the effective herbicide to the environmental contaminant: A review of recent studies on quinclorac. Song D., Jiang X., Wang D., Fang S., Zhou H., Kong F.. 2022

[8]Encapsulated allyl isothiocyanate improves soil distribution, efficacy against soil-borne pathogens and tomato yield. Zhang, Yi,Fang, Wensheng,Yan, Dongdong,Ji, Yutong,Chen, Xinhua,Guo, Anmin,Song, Zhaoxin,Li, Yuan,Cao, Aocheng,Wang, Qiuxia. 2024

[9]Stereoselective dissipation of epoxiconazole in grape (Vitis vinifera cv. Kyoho) and soil under field conditions. Liang, Hongwu,Li, Li,Li, Wei,Qiu, Jing,Liang, Hongwu,Zhou, Zhiqiang,Liu, Fengmao,Qiu, Lihong.

[10]An efficient synthesis of a dimer of the tetrasaccharide present in motif B of the Mycobacterium tuberculosis cell wall. Ning, J.

[11]Chiral fungicide triadimefon and triadimenol: Stereoselective transformation in greenhouse crops and soil, and toxicity to Daphnia magna. Dong, Fengshou,Liu, Xingang,Xu, Jun,Han, Yongtao,Zheng, Yongquan.

[12]The integration of in vivo and in vitro metabolism assays to investigate the stereoselective behaviors of benalaxyl in rainbow trout (Oncorhynchus mykiss). Gu, Xu,Gu, Xu,Yao, Ting. 2013

[13]Stereoselective Pharmacokinetics of Diniconazole Enantiomers in Rabbits. Cao, Aocheng,Qiu, Jing,Zhou, Zhiqiang,Zhu, Wentao,Dang, Ziheng,Wang, Xinquan.

[14]Stereoselective Degradation of Fungicide Triadimenol in Cucumber Plants. Liu, Xingang,Zheng, Yongquan,Cao, Qiao,Dong, Fengshou,Li, Chongjiu,Dong, Fengshou,Liu, Xingang,Zheng, Yongquan,Li, Chongjiu.

[15]Enantioselective determination of triazole fungice tetraconazole by chiral high-performance liquid chromatography and its application to pharmacokinetic study in cucumber, muskmelon, and soils. Dong, Fengshou,Xu, Jun,Liu, Xingang,Li, Yuanbo,Zheng, Yongquan,Shan, Weili.

[16]Influence of Uptake Pathways on the Stereoselective Dissipation of Chiral Neonicotinoid Sulfoxaflor in Greenhouse Vegetables. Dong, Fengshou,Pan, Xinglu,Xu, Jun,Liu, Xingang,Wu, Xiaohu,Zheng, Yongquan.

[17]Integrating high-throughput sequencing and metabolomics to investigate the stereoselective responses of soil microorganisms to chiral fungicide cis-epoxiconazole. Pengfei Xue,Xiaowei Liu,Liuqing Zhao,Jingran Zhang,Zeying He. 2022

[18]Stereoselective Bioactivity and Action Mechanism of the Fungicide Isopyrazam. Guo, Peilin,Ren, Yuqi,Pan, Xinglu,Xu, Jun,Wu, Xiaohu,Zheng, Yongquan,Du, Fengpei,Dong, Fengshou. 2024

[19]Different influences of field aging on nickel toxicity to Folsomia candida in two types of soil. Liu, Yu-Rong,Li, Jing,He, Ji-Zheng,Zheng, Yuan-Ming,Ma, Yi-Bing.

[20]Quantitative source apportionment, risk assessment and distribution of heavy metals in agricultural soils from southern Shandong Peninsula of China. Haiwei Liu,Yan Zhang,Jiashuo Yang,Haiyun Wang,Yile Li,Yi Shi,Decheng Li,Peter E. Holm,Quan Ou,Wenyou Hu. 2021

作者其他论文 更多>>