数字农科院2.0

Multiomics analysis reveals that microbiota regulate fat and muscle synthesis in chickens

文献类型： 外文期刊

作者： Hai Chang Yin;Wan Qi Yao;He Zhang;Song Liu;Tian Yi Ma;Chang You Xia

作者机构：

关键词： fat accumulation;GF chicken;intestinal microbes;metabolism;muscle development

期刊名称： Poultry Science

ISSN： 0032-5791

年卷期： 2024 年 103 卷 3 期

页码：

收录情况： SCIE（2024版）

摘要： Intestinal microbiota regulates the host metabolism, including fat metabolism and muscle development in mammals; however, studies on the interactions between the gut microbiome and in chickens with respect to fat metabolism and muscle development are still rare. We established a germ-free (GF) chicken model to determine the transcriptomes and metabolomes of GF and specific-pathogen-free (SPF) chickens. Transcriptome analysis showed 1,282 differentially expressed genes (DEGs) in GF and SPF chickens. The expression levels of some genes related to muscle formation were very high in SPF chickens but low in GF chickens, suggesting that GF chickens had poorer muscle development ability. In contrast, the expression levels of some fat synthesis-related genes were very low in SPF chickens but high in GF chickens, suggesting that GF chickens had a more potent fat-synthesizing ability. Metabolome analysis revealed 62 differentially expressed metabolites (DEMs) in GF and SPF chickens, of which 35 were upregulated and 27 were downregulated. Furthermore, the Pearson correlation coefficient (PCC) was calculated, and an interaction network was constructed to visualize the crosstalk between the genes, metabolites, and gut microbiota in GF and SPF chickens. The top 10 gut microbiota were positively correlated with lipid metabolism including13(S)-HpODE and 9(S)-HpOTrE, and genes related to muscle development, while were negatively correlated with genes related to fat synthesis. In conclusion, this study indicated that chicken intestinal microbiota regulate host metabolism, inhibit fat synthesis, and may promote muscle development.

分类号：

  • 相关文献

[1]Mini-review: microbiota have potential to prevent PEDV infection by improved intestinal barrier. Yang, Shanshan,Liu, Guangliang,Savelkoul, Huub F. J.,Jansen, Christine A.,Li, Bin. 2023

[2]Expression of ADAMTS4 and ADAMTS5 in longissimus dorsi muscle related to meat tenderness in Nanyang cattle. Zhang, X. H.,Qi, Y. X.,Gao, X.,Li, J. Y.,Xu, S. Z.. 2013

[3]Molecular characterization of the BTG2 and BTG3 genes in fetal muscle development of pigs. Feng, Zheng,Tang, Zhong-Lin,Li, Kui,Liu, Bang,Yu, Mei,Zhao, Shu-Hong. 2007

[4]Characterization of microRNAs from sheep (Ovis aries) using computational and experimental analyses. Sheng, Xihui,Wei, Caihong,Liu, Tao,Zhang, Li,Du, Lixin,Sheng, Xihui,Song, Xuemei,Yu, Yan,Niu, Lili,Li, Shangang,Li, Hongbin.

[5]Effects of dietary supplementation of probiotics (Bacillus subtilis, Bacillus licheniformis, and Bacillus natto) on broiler muscle development and meat quality. Zhou, Xianjian,Jin, Erhui,Li, Shenghe,Wang, Chenfang,Qiao, Enmei,Li, Shenghe,Wu, Guozhong.

[6]Transcriptome analysis reveals that constant heat stress modifies the metabolism and structure of the porcine longissimus dorsi skeletal muscle. Hao, Yue,Feng, Yuejin,Yang, Peige,Cui, Yanjun,Liu, Jiru,Yang, Chunhe,Gu, Xianhong,Liu, Jiru.

[7]Molecular Characterization of Tob1 in Muscle Development in Pigs. Yuan, Jing,Cao, Ji-Yue,Yuan, Jing,Tang, Zhong-Lin,Li, Kui,Wang, Ning. 2011

[8]Identification And Characterization Of Long N.oncoding Rnas In Ovine S keletal Muscle. Li, Q, Liu, RZ, Zhao, HJ, Di, R, Lu, ZK, Liu, EM, Wang, YQ, Chu, MX, Wei, CH. 2018

[9]Effect of Cage and Floor Housing Systems on Muscle Fiber Characteristics, Carcass Characteristics, and Meat Quality of Slow-Growing Meat-Type Chickens. Yanyan Sun,Chen Liu,Yunlei Li,Dongli Li,Lei Shi,Jilan Chen. 2023

[10]Transcriptome-Wide Study of mRNAs and lncRNAs Modified by m6A RNA Methylation in the Longissimus Dorsi Muscle Development of Cattle-Yak. Chun Huang,Rongfeng Dai,Guangyao Meng,Renqing Dingkao,Xingdong Wang,Wenwen Ren,Xiaoming Ma,Xiaoyun Wu,Min Chu,Yongfu La,Pengjia Bao,Xian Guo,Jie Pei,Ping Yan,Chunnian Liang. 2022

[11]Regulatory Role of N6-Methyladenosine in Longissimus Dorsi Development in Yak. Xiaoming Ma,Yongfu La,Pengjia Bao,Min Chu,Xian Guo,Xiaoyun Wu,Jie Pei,Xuezhi Ding,Chunnian Liang,Ping Yan. 2022

[12]The Role of Incubation Conditions on the Regulation of Muscle Development and Meat Quality in Poultry. Wang, Yuan-Hao,Lin, Jing,Wang, Jing,Wu, Shu-Geng,Qiu, Kai,Zhang, Hai-Jun,Qi, Guang-Hai. 2022

[13]A 1.1 Mb duplication CNV on chromosome 17 contributes to skeletal muscle development in Boer goats. Yuan Y.,Zhang W.-Y.,Yang B.-G.,Zhou D.-K.,Xu L.,He Y.-M.,Zhang H.-Y.,Liu C.-L.,Ma Y.-H.,Chu M.-X.,Zhang W.-G.,Gao H.-J.,Jiang L.,Zhao F.-P.,Zhang L.-P.,Na R.-S.,Oyungerel B.,Han Y.-G.,Zeng Y.,Wang S.-Z.,Jiang H.-Z.,Zhang H.-P.,Jiang X.-P.,He J.-N.,Liang H.,Kaushalendra K.,Sun Y.-W.,Huang Y.-F.,Zhao Y.-J.,Zhao Z.-Q.,E G.-X.. 2023

[14]Transcriptomics and metabolomics reveal improved performance of Hu sheep on hybridization with Southdown sheep. Lingying Kong,Yaojing Yue,Jianye Li,Bohui Yang,Bowen Chen,Jianbin Liu,Zengkui Lu. 2023

[15]Muscle Transcriptome Analysis of Mink at Different Growth Stages Using RNA-Seq. Min Rong,Xiumei Xing,Ranran Zhang. 2024

[16]Whole-transcriptome analysis of longissimus dorsi muscle in cattle-yaks reveals the regulatory functions of ADAMTS6 gene in myoblasts. Chun Huang,Fen Feng,Rongfeng Dai,Wenwen Ren,Xinyi Li,Ta Zhaxi,Xiaoming Ma,Xiaoyun Wu,Min Chu,Yongfu La,Pengjia Bao,Xian Guo,Jie Pei,Ping Yan,Chunnian Liang. 2024

[17]Estrogen-induced circFAM171A1 regulates sheep myoblast proliferation through the oar-miR-485-5p/MAPK15/MAPK pathway. Runqing Chi,Yufang Liu,Peng Wang,Fan Yang,Xiangyu Wang,Xiaoyun He,Ran Di,Mingxing Chu. 2025

[18]Maternal Supplementation of Collagen Peptide Chelated Trace Elements Enhances Skeletal Muscle Development in Chicks. Wang, Jiao,Huang, Zhenwu,Li, Simeng,Lv, Zengpeng. 2024

[19]Genome-Wide Association Integrating a Transcriptomic Meta-Analysis Suggests That Genes Related to Fat Deposition and Muscle Development Are Closely Associated with Growth in Huaxi Cattle. Cheng Li Liu,Tao Ren,Peng Cheng Ruan,Yong Fu Huang,Simone Ceccobelli,De Jun Huang,Lu Pei Zhang,Guang Xin E. 2025

[20]Genome-wide identification and characterization of the ubiquitin-specific protease (USP) gene family in cattle: primary analysis of muscle-specific USP genes and their influence on myogenesis. Yufei Zan,Junliang Li,Fengcheng Song,Yixuan Tang,Yuxuan Xin,Zhepei Zhang,Linjuan Wang,Lupei Zhang,Liang Du,Zhengrong Yuan,Xue Gao. 2025

作者其他论文 更多>>