数字农科院2.0

Natural Extracts From White Common Bean (Phaseolus Vulgaris L.) Inhibit 3T3-L1 Adipocytes Differentiation

文献类型： 外文期刊

作者： Shi; ZX; Zhang; X; Zhu; YY; Yao; Y; Ren; GX

关键词： Common Bean; Polyphenol; Alpha-Amylase Inhibitor; Non-Starch Polysaccharides; 3T3-L1

期刊名称： Applied Sciences-Basel

ISSN： 2076-3417

年卷期： 2021 年 11 卷 1 期

页码：

收录情况： JCR（2021版）

摘要： Background: Recent studies have shown that the consumption of common bean (Phaseolus vulgaris L.) foods plays an essential role in the prevention and treatment of obesity. Methods: In this study, different natural extracts that include common bean polyphenol-rich extract (CBP), alpha-amylase inhibitor-rich extract (alpha-AIE), and non-starch polysaccharides-rich extract (NSP) were isolated. Their effects on 3T3-L1 adipocytes differentiation were evaluated, respectively. Results: The results showed that CPB reduced the lipid content in the mature adipocytes to 79.29% (150 mu g/mL) and 35.13% (300 mu g/mL), and alpha-AIE reduced it to 90.20% (2 mg/mL) and 68.28% (4 mg/mL), while NSP exhibited an auxo-action, suggesting that both CBP and a-AIE inhibited 3T3-L1 adipocytes differentiation. Additionally, CBP significantly suppressed (p < 0.05) the mRNA expression level and the protein expression level of peroxisome proliferator-activated receptor gamma (PPAR gamma), CCAAT-enhancer-binding protein alpha (C/EBP alpha), sterol-regulatory element binding proteins 1 c (SREBP-1c), lipoprotein lipase (LPL), and fatty acid binding protein (ap2). Meanwhile, alpha-AIE only showed significant suppression effects on PPAR gamma, C/EBP alpha, and ap2 at the high dose of 4 mg/mL (p < 0.05). Conclusions: These findings indicate that CBP, from white common bean, might be the major component responsible for the inhibitory effects on adipocyte differentiation.

分类号：

  • 相关文献

[1]Comparisons of phaseolin type and α-amylase inhibitor in common bean (Phaseolus vulgaris L.) in China. Yang Yao,Yibo Hu,Yingying Zhu,Yue Gao,GuixingRen. 2016

[2]Significantly Increased Amino Acid Accumulation I.n A Novel Albino B ranch Of The Tea Plant (Camellia Sinensis). Yang, Tianyuan,Wang, Rangjian,Zhang, Zheng-Zhu,Jia, Huiyan,Zhu, Biying,Deng, Wei-Wei,Han, Jieyun,Lu, Mengqian. 2019

[3]Freezing Stress Deteriorates Tea Quality O.f New Flush By I nducing Photosynthetic Inhibition And Oxidative Stress In Mature Leaves. Li, X, Aharnmed, GJ, Li, ZX, Zhang, L, Wei, JP, Yan, P, Zhang, LP, Han, WY. 2018

[4]Dietary Supplementation With Mulberry Leaf F.lavonoids Inhibits Methanogenesis In S heep. Ma, T, Chen, DD, Tu, Y, Zhang, NF, Si, BW, Diao, QY. 2017

[5]Investigation on the phenolic composition, related oxidation and antioxidant activity of thinned peach dried by different methods. Guo Chongting,Bi Jinfeng,Li Xuan,Lyu Jian,Xu Ye,Hu Jiaxing. 2021

[6]The roles of soluble poly and insoluble tannin in the enzymatic browning during storage of dried persimmon. Zhou M., Chen J., Bi J., Li X., Xin G.. 2022

[7]Modelling and optimization of high-pressure homogenization of not-from-concentrate juice: Achieving better juice quality using sustainable production. Liu J., Bi J., Liu X., Liu D., Verkerk R., Dekker M., Lyu J., Wu X.. 2022

[8]Functionalization of sweet potato leaf polyphenols by nanostructured composite β-lactoglobulin particles from molecular level complexations: A review. Makori S.I., Mu T.-H., Sun H.-N.. 2022

[9]Quantitative conversion of free, acid-hydrolyzable, and bound ellagic acid in walnut kernels during baking. Guo X., Gu F., Yang T., Shao Z., Zhang Q., Zhu J., Wang F.. 2023

[10]The In Vivo Antioxidant And Hepatoprotective Actions Of Selected Chinese Teas. Cao, SY, Li, BY, Gan, RY, Mao, QQ, Wang, YF, Shang, A, Meng, JM, Xu, XY, Wei, XL, Li, HB. 2020

[11]Antibacterial Activity Of Polyphenols: Structure-Activity R.elationship And Influence Of H yperglycemic Condition. Xie, YX, Chen, J, Xiao, AP, Liu, LL. 2017

[12]Phenolic Profiles And Antioxidant Activities O.f 30 Tea Infusions F rom Green, Black, Oolong, White, Yellow And Dark Teas. Zhao, CN, Tang, GY, Cao, SY, Xu, XY, Gan, RY, Liu, Q, Mao, QQ, Shang, A, Li, HB. 2019

[13]Genome-Wide Investigation of WRKY Transcription Factors Involved in Terminal Drought Stress Response in Common Bean. Wu, Jing,Wang, Lanfen,Wang, Shumin,Chen, Jibao. 2016

[14]Salicylic Acid Enhances Resistance to Fusarium oxysporum f. sp. phaseoli in Common Beans (Phaseolus vulgaris L.). Xue, Ren Feng,Wu, Jing,Wang, Lan Fen,Wang, Xiao Ming,Zhu, Zhen Dong,Wang, Shu Min,Xue, Ren Feng,Ge, Wei De,Blair, Matthew W.. 2014

[15]Comparisons of phaseolin type and alpha-amylase inhibitor in common bean (Phaseolus vulgaris L.) in China. Yao, Yang,Hu, Yibo,Zhu, Yingying,Gao, Yue,Ren, Guixing. 2016

[16]Two P5CS genes from common bean exhibiting different tolerance to salt stress in transgenic Arabidopsis. Chen, Ji Bao,Yang, Jian Wei,Zhang, Zhao Yuan,Feng, Xiao Fan,Wang, Shu Min.

[17]Molecular cloning and characterization of a gene encoding the proline transporter protein in common bean (Phaseolus vulgaris L.). Chen, Jibao,Lu, Yunfeng,Cao, Yuannan,Zeng, Hui,Zhang, Zhaoyuan,Wang, Lanfen,Wang, Shumin. 2016

[18]Comprehensive analysis and discovery of drought-related NAC transcription factors in common bean. Jing Wu,Lanfen Wang,Shumin Wang. 2016

[19]Genome-Wide Association Study Identifies Nbs-Lrr-Encoding G.enes Related With Anthracnose A nd Common Bacterial Blight In The Common Bean. Wu, J, Zhu, JF, Wang, LF, Wang, SM. 2017

[20]Cloning of the OAT gene and the correlation between its expression and drought tolerance in Phaseolus vulgaris L.. CHEN Ji-bao,CAO Yuan-nan,ZHANG Zhao-yuan,WANG Shu-min, WU Jing,WANG Lan-fen. 2016

作者其他论文 更多>>