数字农科院2.0

Metabolomic analysis of the serum and urine of rats exposed to diazinon, dimethoate, and cypermethrin alone or in combination

文献类型： 外文期刊

作者： Liang Y.-J.;Long D.-X.;Wang S.;Wang H.-P.;Wu Y.-J.

作者机构：

关键词： Metabolomics analysis;Multiple-pesticide exposure;Organophosphate;Pyrethroid;Subacute toxicity

期刊名称： BMC Pharmacology and Toxicology

ISSN： 2050-6511

年卷期： 2024 年 25 卷 1 期

页码：

收录情况： SCIE（2024版）

摘要： Background: Multiple pesticides are often used in combination for plant protection and public health. Therefore, it is important to analyze the physiological changes induced by multiple pesticides exposure. The objective of this study was to investigate the combined toxicity of the widely-used organophosphorus and pyrethroid pesticides diazinon, dimethoate, and cypermethrin. Methods: Male Wistar rats were administrated by gavage once daily with the three pesticides individual or in combination for consecutive 28 days. The metabolic components of serum and urine samples were detected by using 1H nuclear magnetic resonance (NMR)-based metabolomics method. Histopathological examination of liver and kidneys and serum biochemical determination were also carried out. Results: The results showed that after the 28-day subacute exposure, serum glutamic transaminase and albumin were significantly increased and blood urea nitrogen was significantly decreased in the rats exposed to the mixture of the pesticides compared with the control rats, suggesting that the co-exposure impaired liver and kidney function. Metabolomics analysis indicated that the indicators 14 metabolites were statistically significant altered in the rats after the exposure of the pesticides. The increase in 3-hydroxybutyric acid in urine or decrease of lactate and N-acetyl-L-cysteine in serum could be a potentially sensitive biomarker of the subchronic combined effects of the three insecticides. The reduction level of 2-oxoglutarate and creatinine in urine may be indicative of dysfunction of liver and kidneys. Conclusion: In summary, the exposure of rats to pesticides diazinon, dimethoate, and cypermethrin could cause disorder of lipid and amino acid metabolism, induction of oxidative stress, and dysfunction of liver and kidneys, which contributes to the understanding of combined toxic effects of the pesticides revealed by using the metabolomics analysis of the urine and serum profiles. © 2023, The Author(s).

分类号：

  • 相关文献

[1]Duplication of acetylcholinesterase gene in diamondback moth strains with different sensitivities to acephate. Shi, Xueyan,Song, Dunlun,Liang, Pei,Gao, Xiwu,Zhang, Youjun,Li, Jianhong,Liu, Yong,Li, Ming,Matsumura, Masaya,Sanada-Morimura, Sachiyo,Minakuchi, Chieka,Tanaka, Toshiharu,Miyata, Tadashi. 2014

[2]Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate. Yuan Fan,Yunxing Fu,Yuhang Zhou,Yu Liu,Baocheng Hao,Ruofeng Shang. 2022

[3]Differences in Toxicity Induced by Varying Degrees of Polymerization of Tristyrylphenol Ethoxylates in Male Mice. Li, Chunmei,Jin, Fen,Wang, Fengzhong,Fan, Bei. 2025

[4]Prediction of Chinese green tea ranking by metabolite profiling using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). Jing, Jin,Wang, Jie,Jing, Jin,Shi, Yuanzhi,Zhang, Qunfeng,Wang, Jie,Ruan, Jianyun,Shi, Yuanzhi,Zhang, Qunfeng,Ruan, Jianyun.

[5]Frequencies of the M918I mutation in the sodium channel of the diamondback moth in China, Thailand and Japan and its association with pyrethroid resistance. Wari, David,Shi, Xueyan,Song, Dunlun,Liang, Pei,Gao, Xiwu,Zhang, Youjun,Li, Jianhong,Wu, Gang,Liu, Yong,Li, Ming,Matsumura, Masaya,Minakuchi, Chieka,Tanaka, Toshiharu,Miyata, Tadashi. 2012

[6]Lc50 Of Lambda-Cyhalothrin Stimulates Reproduction O.n The Moth Mythimna S eparata (Walker). Li, Xin-Ru,Li, Yue,He, Ning,Yang, Xue-Qing,Wang, Wei,Tan, Xiao-Ling. 2019

[7]Alternative splicing of a carboxyl/choline esterase gene enhances the fenpropathrin tolerance of Tetranychus cinnabarinus. Wei, Peng,Zeng, Xinying,Han, Haonan,Yang, Yiqing,Zhang, Youjun,He, Lin. 2022

[8]The water-exiting behavior and survival of predaceous diving beetles in responses to lambda-cyhalothrin, chlorantraniliprole, and thiamethoxam. Wang L.,Liu L.,Feng S.. 2024

[9]Toxicity mechanism of organosilicon adjuvant in combination with S-metolachlor on Vigna angularis. Qian Zhao,Zhenduo Yang,Ziyuan Zhou,Yuewei Yang,Wei Wang. 2024

[10]Effect of ultrasonic treatment on the microstructure, antioxidant activities and metabolites of camellia bee pollen. Yanxiang Bi,Shiye Luo,Jiabao Ni,Song Miao,Zhen Ning,Zhihao Zhang,Sijia Xu,Wenli Tian,Wenjun Peng,Xiaoming Fang. 2025

[11]Detection of Cereibacter azotoformans-YS02 as a Novel Source of Coenzyme Q10 and Its Metabolic Analysis. Song, Meijie,Xu, Qianqian,Raka, Rifat Nowshin,Yin, Chunhua,Liu, Xiaolu,Yan, Hai. 2025

作者其他论文 更多>>