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Serum Spermidine in Relation to Risk of Stroke: A Multilevel Study

文献类型： 外文期刊

作者： Liqiang Zheng;Yanxia Xie;Zhaoqing Sun;Rui Zhang;Yanan Ma;Jiahui Xu;Jia Zheng;Qianyi Xu;Zhao Li;Xiaofan Guo;Guozhe Sun;Fuguo Xing;Yingxian Sun;Deliang Wen

作者机构：

关键词： cardiovascular disease;epidemiology;nested case-control study;spermidine;stroke

期刊名称： Frontiers in Nutrition

ISSN： 2296-861X

年卷期： 2022 年 9 卷

页码：

收录情况： SCIE（2022版）

摘要： The relationship between serum spermidine levels and future cardiovascular disease risk has not yet been well elucidated in the general population based on community studies. Using a nested case-control study, we estimated the association between serum spermidine level and future stroke. New stroke cases had higher baseline levels of spermidine than controls [182.8 (141.8–231.5) vs. 152.0 (124.3–193.0), P < 0.001]. After multivariable adjustment, individuals with spermidine ≥ 205.9 nmol/L (T3) higher risks of stroke (HR 5.02, 95% CI 1.58–16.02) with the lowest quartile (< 136.9 nmol/L) as reference. The association between serum spermidine levels and risk of stroke seemed to be consistent and was reproducible in our cross-sectional studies. In addition, comparisons of the areas under receiver operator characteristics curves confirmed that a model including spermidine had better discrimination than without (0.755 vs. 0.715, P = 0.04). Here we report a close relationship exists between serum spermidine levels and risk of stroke.

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