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Vimentin inhibits peste des petits ruminants virus replication by interaction with nucleocapsid protein

文献类型： 外文期刊

作者： Long Xu;Jingjing Ren;Lingxia Li;Mengyi Wang;Guoqiang Zhu;Haixue Zheng;Qiaoying Zeng;Youjun Shang;Dan Li

作者机构：

关键词： Nucleocapsid protein;Peste des petits ruminant virus;Ubiquitin;Vimentin;Viral replication

期刊名称： Virology

ISSN： 0042-6822

年卷期： 2024 年 595 卷

页码：

收录情况： SCIE（2024版）

摘要： The Peste des petits ruminant virus (PPRV) is a member of the Paramyxoviridae family and is classified into the genus Measles virus. PPRV predominantly infects small ruminants, leading to mortality rates of nearly 100%, which have caused significant economic losses in developing countries. Host proteins are important in virus replication, but the PPRV nucleocapsid (N) protein-host interacting partners for regulating PPRV replication remain unclear. The present study confirmed the interaction between PPRV-N and the host protein vimentin by co-immunoprecipitation and co-localization experiments. Overexpression of vimentin suppressed PPRV replication, whereas vimentin knockdown had the opposite effect. Mechanistically, N was subjected to degradation via the ubiquitin/proteasome pathway, where vimentin recruits the E3 ubiquitin ligase NEDD4L to fulfill N-ubiquitination, resulting in the degradation of the N protein. These findings suggest that the host protein vimentin and E3 ubiquitin ligase NEDD4L have an anti-PPRV effect.

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